Results 91 to 100 of about 6,225,690 (315)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Twelve quick tips for software design. [PDF]

PLoS Comput Biol, 2022
Wilson G.
europepmc   +1 more source

Instructional Design and Application based on Process fortified assessment to enhance Students’ Procedural Thinking ability in Software Education in Elementary School

, 2022
Hwakyung Rim, Hyung-Mo Ahn
openalex   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

A Survey on Autism Care, Diagnosis, and Intervention Based on Mobile Apps Focusing on Usability and Software Design. [PDF]

Sensors (Basel), 2023
Liu X, Zhao W, Qi Q, Luo X.
europepmc   +1 more source

Education Software Design of Faculty Room for Energy Efficiency [PDF]

, 2015
Nowadays, Global Warming has become a new issue whom impact can be very devastating and can threat the earth and human existence in the future. Since the impact can be very dangerous, many efforts have been done and many ideas have been proposed to ...
Isnanda, R. G. (Reza)
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Design and Application of Drainage and Gas Recovery Process Parameters of Concentric Dual Tubing Jet Pump

Shiyou jixie, 2020
The researches on the drainage and gas recovery technology of concentric dual-tubing jet pump mainly focus on the structural design of the jet pump core, or a brief introduction to the production process of jet pump.
Yu Jiaojiao, Li Youwu, Li Lezhong, Cui Jingyun, Zhang Yue, Jia Zongwen   +5 more
doaj  

Depth Estimation From a Light Field Image Pair With a Generative Model

IEEE Access, 2019
In this paper, we propose a novel method to estimate the disparity maps from a light field image pair captured by a pair of light field cameras. Our method integrates two types of critical depth cues, which are separately inferred from the epipolar plane
Tao Yan, Fan Zhang, Yiming Mao, Hongbin Yu, Xiaohua Qian, Rynson W. H. Lau   +5 more
doaj   +1 more source