Results 91 to 100 of about 15,432,329 (305)

Engineering education : being the proceedings of Section E of the World's Engineering Congress.

open access: yes, 1894
"Published by the Society for the Promotion of Engineering Education as volume 1 of their proceedings."Mode of access ...
Society for the Promotion of Engineering Education (U.S.)   +1 more
core  

Enhancing Engineering Education Through Faculty-Library Collaboration [Paper]

open access: yes
Paper highlighting a research project that explored student and faculty needs and activities in engineering at the University of North Texas. It was presented at the American Society of Engineering Education (ASEE) Gulf Southwest Conference in March ...
Miles, Chassidy   +2 more
core   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

open access: yesMolecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee   +3 more
wiley   +1 more source

CREATIVE ENGINEERING APPROACH FOR PERSISTENT SIMULATION OF ENGINEERING SYSTEMS IN SOFTWARE ENVIRONMENTS

open access: yesآموزش مهندسی ایران
Engineering education, alongside various fields of engineering, requires research and importance. In engineering sciences, numerical simulation using computer software is one of the important research tools for engineers.
Mansouri Amirhosein   +1 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

Design of aperture radar auxiliary technology based on array mathematical model and statistical characteristic calculation

open access: yesDiscover Applied Sciences
In response to the problem of poor imaging quality caused by amplitude and phase errors in synthetic aperture imaging, this study develops an aperture radar-assisted technology based on an array of mathematical models and statistical characteristic ...
Ji Yang, Ying Fan, Shuqing Yang
doaj   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

open access: yesMolecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh   +11 more
wiley   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

open access: yesMolecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault   +12 more
wiley   +1 more source

The Newcomers: Humanities in Engineering Education

open access: yes, 2007
– Engineering education has undergone a progressive specialization, creating a professional figure far from the ideal of the Italian Renaissance “artifex”, who united technical skills with a deep humanistic education.
RUSSO, MARIA TERESA
core  

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

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