Results 71 to 80 of about 15,432,329 (305)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Configurable and computable instructional model based on gamification elements: a case study on education in software engineering

Apertura, 2020
This article describes a configurable and computable instructional model based on gamification elements. The empirical evaluation of the model is also reported using the software engineering area as the scope of application; in the experimental study two
Raúl Antonio Aguilar Vera, Érika Eunice Briceño Arceo, Julio César Díaz Mendoza, Juan Pablo Ucán Pech   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Towards a European master programme on global software engineering [PDF]

, 2007
This paper presents a European Master programme on global software engineering (SE), being put forward by four leading institutions from Sweden, UK, Netherlands and Italy.
Patricia Lago, Crnkovic, Ivica,, Beus-Dukic, L., Lago, P.; id_orcid, Lago, P., Ivica Crnkovic, Van Vliet, Hans,, Muccini, Henry,, Punnekkat, S., Sasikumar Punnekkat, Punnekkat, Sasikumar,, Hans Van Vliet, Ljerka Beus-Dukic, Beus-Dukic, Ljerka,, Crnkovoc, I., Muccini, H., Crnkovic, I., Lago, Patricia,, Henry Muccini, Van Vliet, H.   +19 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Secure Software Engineering Education: Knowledge Area, Curriculum and Resources

Journal of Cybersecurity Education, Research & Practice, 2016
This paper reviews current efforts and resources in secure software engineering education, with the goal of providing guidance for educators to make use of these resources in developing secure software engineering curriculum.
Xiaohong Yuan, Li Yang, Bilan Jones, Huiming Yu, Bei-Tseng Chu   +4 more
doaj  

2nd Workshop on Innovative Software Engineering Education

, 2019
This workshop aims at presenting and discussing innovative teaching approaches in software engineering education, which are highly relevant for teaching at universities, colleges, and in online courses.
Schneider, Kurt, Krusche, Stephan, Kuhrmann, Marco   +2 more
core   +1 more source

Work in Progress: Intelligent Tutoring Systems in Computer Science and Software Engineering Education [PDF]

, 2015
Work in Progress: Intelligent Tutoring Systems in Computer Science and Software Engineering EducationQuantitative analysis of bibliographic databases indicates that research on intelligent tutoringsystems (ITS) has accelerated over the last decade and ...
Liu, Qing, Liu, Li, Adesope, Olusola O, Nesbit, John C, Olusola Adesope, Li Liu, Qing Liu, John Nesbit   +7 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source