Results 51 to 60 of about 14,644,049 (303)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Curriculum Issues in Industry Oriented Software Engineering Education

, 2012
Mishra, Deepti/0000-0001-5144-3811; Mishra, Alok/0000-0003-1275-2050Software engineering education has been emerging as an independent and mature discipline.
Mıshra, Deepti, Mishra, Deepti, Mishra, Alok, Mıshra, Alok   +3 more
core   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Teaching Software Engineering in K-12 Education: A Systematic Mapping Study

Informatics in Education, 2018
Diverse initiatives have emerged to popularize the teaching of computing in K-12 mainly through programming. This, however, may not cover other important core computing competencies, such as Software Engineering (SE). Thus, in order to obtain an overview
Fernando da CRUZ PINHEIRO, Christiane Gresse von WANGENHEIM, Raul MISSFELDT FILHO   +2 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Software startup within a university - producing industry-ready graduates

, 2023
Previous research has demonstrated that preparing students for life in software engineering is not a trivial task. Authentic learning experiences are challenging to provide, and there are gaps between what students have done at the university and what ...
Ihantola, Petri, Luukkainen, Matti, Tenhunen, Saara Maija, Kousa, Jami, Männistö, Tomi   +4 more
core   +1 more source

Analysis of cost estimation using the web metrics and cost driver in the high performance of web developers

Automatika, 2023
In recent years, many researchers and software industries have given significant attention to the estimation of software effort. Software effort estimation is a challenge that often appears in the project of making software.
A. Salinda Eveline Suniram, J. Charles
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Software engineering support activities for very small entities [PDF]

, 2010
The emerging ISO/IEC 29110 standard Lifecycle profiles for Very Small Entities has at its core a Management and Engineering Guides which is targeted at very small entity (enterprise, organization, department or project) having up to 25 people, to assist ...
Laporte, Claude Y., Vincent Ribaud (12588838), O\u27Connor, Rory V., O\u27Connor, Rory, Saliou, Philippe, O'Connor, Rory, Claude Y. Laporte, Laporte, Claude, Claude Y. Laporte (12588841), Philippe Saliou, Rory V. O’Connor, Vincent Ribaud, Philippe Saliou (493495), Ribaud, Vincent, Rory V. O'Connor (12588769)   +14 more
core   +2 more sources

A Comprehensive Assessment Plan for Accreditation in Engineering Education: A Case Study in Turkey

, 2015
Sengul, Gokhan/0000-0003-2273-4411; Koyuncu, Murat/0000-0003-1958-5945; Turhan, Cigdem/0000-0002-6595-7095This paper describes the procedure followed by Computer Engineering and Software Engineering programs at Atilim University, Ankara, Turkey, which ...
Turhan, Cigdem, Sengul, Gokhan, Koyuncu, Murat   +2 more
core   +2 more sources