Results 41 to 50 of about 1,059,350 (301)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
IEEE Access, 2022 Software modeling is a creative activity in which software components and their relationships are identified based on customer requirements. Based on the literature, object-oriented software modeling is based on four fundamental pillars which are ...
Pamela Flores +2 more
doaj +1 more source
Teaching Software Engineering through Robotics [PDF]
, 2014 This paper presents a newly-developed robotics programming course and reports the initial results of software engineering education in robotics context. Robotics programming, as a multidisciplinary course, puts equal emphasis on software engineering and ...
Meyer, Bertrand +2 more
core
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Adaption of a Secure Software Development Methodology for Secure Engineering Design
IEEE Access, 2020 With the rapid advancement of technologies in the era of Industry 4.0, the inter-connected nature of operations and systems is introducing a rapidly changing landscape of digitized and connected systems.
Sune Von Solms, Lynn A. Futcher
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
On the Presence of Green and Sustainable Software Engineering in Higher Education Curricula
, 2017 Nowadays, software is pervasive in our everyday lives. Its sustainability and environmental impact have become major factors to be considered in the development of software systems. Millennials-the newer generation of university students-are particularly
Fucci, Davide +4 more
core +1 more source
One system, two ideologies: integrating the two worlds of software engineering education [PDF]
, 1999 In software engineering education, there are two contradicting ideologies. One ideology emphasizes on the popular methods such as object-oriented analysis and design. The other ideology advocates formal methods.
Tse, TH
core +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
IEEE Access, 2019 Unified modeling language (UML) is a modeling standard in the software industry. However, students face difficulties when learning how to model complete and correct UML diagrams, in part because the traditional teacher-centered approach still dominates ...
Williamson Silva +2 more
doaj +1 more source