Results 41 to 50 of about 413,454 (264)

Soft Finger Modelling and Co-Simulation Control towards Assistive Exoskeleton Hand Glove

Micromachines, 2021
The soft pneumatic actuators of an assistive exoskeleton hand glove are here designed. The design of the actuators focuses on allowing the actuator to perform the required bending and to restrict elongation or twisting of the actuator.
Mohammed N. El-Agroudy, Mohammed I. Awad, Shady A. Maged   +2 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Enhancing Safety-Critical Brake System Testing with Vector SIL over Complex Vector HIL

Engineering Proceedings
Advanced vehicle technologies that substitute or assist the driver are crucial and safety-critical elements, including independently acting electronic control units.
János Májer, Dénes Fodor, Péter Panyi, Félix Tivadar Nagy, Balázs István Németh   +4 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Embedded System Simulation Using Renode

Engineering Proceedings
In the automotive industry, the reduction of development costs is of key importance. The development of electrical hardware is an expensive, time-consuming process with a lot of development stages (e.g., prototyping, electrical testing, mechanical ...
Ferenc Speiser, István Szalay, Dénes Fodor   +2 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

The Design and Joint Simulation of Software-in- the-Loop for a Digital Mechatronics Teaching Experimental Platform

IEEE Access
Currently, numerous vocational colleges have incorporated practical training courses focused on automated production lines. However, due to spatial constraints and insufficient availability of physical equipment, the implementation of mechatronic ...
Chong Huang, Ye Zhu, Fuguo Liu
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Real time implementation for robust adaptive sliding mode predictive control of PMSM

Unconventional Resources
Model Predictive Control is recognized as a promising approach for electric drives, with particular interest in the development of robust and high-performance predictive models.
Rachid Ibrahimi, Mohamed said Adouairi, Abdennabi Morchid, Badre Bossoufi, Paweł Skruch, Saleh Mobayen   +5 more
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source