Results 91 to 100 of about 1,789,157 (322)

An Empirical Study of a Software Maintenance Process [PDF]

, 1996
This paper describes how a process support tool is used to collect metrics about a major upgrade to our own electronic retail system. An incremental prototyping lifecycle is adopted in which each increment is categorised by an effort type and a project ...
Harrison, Rachel, Nithi, R., Phalp, Keith T., Samaraweera, L.G., Smith, A.P.   +4 more
core  

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

Dose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment

Molecular Oncology, EarlyView.
Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop, Edgar Cardenas De La Hoz, Hanne Verswyvel, Joey De Backer, Ho Wa Lau, Angela Privat‐Maldonado, Wim Vanden Berghe, Steve Vanlanduit, Evelien Smits, Annemie Bogaerts, Abraham Lin   +10 more
wiley   +1 more source

Reducing maintenance costs through the application of modern software architecture principles [PDF]

, 1999
Christine Hulse, Scott Edgerton, Michael Ubnoske, Louis Vazquez   +3 more
openalex   +2 more sources

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

Molecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed, Lucas Mani, Muhammad Bilal Mirza, Ashtyn McAdoo, Takahito Kondo, Hidenori Tanaka, Nicole Meeks, Eben Rosenthal, Marisa Hom   +8 more
wiley   +1 more source

A Study on the Effect of Traceability Links in Software Maintenance

IEEE Access, 2013
In software development, stakeholders of the same project often collaborate asynchronously through shared artifacts. A traceability system links a project's artifacts and therefore provides support for collaboration among stakeholders.
Khaled Jaber, Bonita Sharif, Chang Liu
doaj   +1 more source

Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment

Molecular Oncology, EarlyView.
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho, Yubin Hah, Eunsik Yun, Hye In Ka, Aram Lee, Sora Han, Dawn Lee, Sung Wook Kim, Jong Hoon Park, Byung Su Kwon, Young Yang, Jongmin Kim   +11 more
wiley   +1 more source

Microservices Evolution Factors: A Multivocal Literature Review

IEEE Access
Microservices is a software architectural approach based on decomposing systems into small services that are simpler and technology-independent for their development and operation.
Sebastian Pinto-Aguero, Rene Noel
doaj   +1 more source

Simplifying the Structural Complexity of Software Systems

Cybernetics and Information Technologies, 2019
Simplification of execution traces is peculiarly important in the case of software comprehension. The objective is to make execution traces in ways that are more tractable and less difficult.
Al-Rousan Thamer, Abualese Hasan
doaj   +1 more source

Issues in Software Maintenance [PDF]

ACM Computing Surveys, 1983
Abstract : Up to a few years ago the area of software maintenance was largely ignored. Interest has increased in the last few years due to several factors. First, the increased volume of enhancement and maintenance with more systems from that of ten years ago has restricted resources available for new development.
openaire   +1 more source