Results 71 to 80 of about 1,868,476 (276)
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Improving Maintenance-Consistency Prediction During Code Clone Creation
IEEE Access, 2020 Developers frequently introduce code clones into software through the copy-and-paste operations during the software development phase in order to shorten development time.
Fanlong Zhang +2 more
doaj +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Microservices Evolution Factors: A Multivocal Literature Review
IEEE AccessMicroservices is a software architectural approach based on decomposing systems into small services that are simpler and technology-independent for their development and operation.
Sebastian Pinto-Aguero, Rene Noel
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
IEEE AccessSoftware quality and long-term maintainability represent fundamental challenges in modern software engineering. Among the critical factors that affect these attributes are code smells, indicators of structural deficiencies in the source code, which ...
Ronald Henry Diaz Arrieta +3 more
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
ADKT: a support tool for reducing architectural knowledge evaporation in software projects
DynaDefining software architecture is a complex task that demands technical expertise and business knowledge. Design decisions drive architectural structures throughout development and maintenance.
Santiago Hyun-Dorado +3 more
doaj +1 more source
Software maintenance in scientific and engineering environments: An introduction and guide [PDF]
The purpose of software maintenance techniques is addressed. The aims of perfective, adaptive and corrective software maintenance are defined and discussed, especially in the NASA research environment. Areas requiring maintenance, and tools available for
Wright, David
core +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source