Results 81 to 90 of about 1,868,476 (276)

Test, Control and Monitor System maintenance plan [PDF]

The maintenance requirements for Test, Control, and Monitor System (TCMS) and the method for satisfying these requirements prior to First Need Date (FND) of the last TCMS set are described. The method for satisfying maintenance requirements following FND
Buehler, David P., Lougheed, M. J.
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

AgentReport: A Multi-Agent LLM Approach for Automated and Reproducible Bug Report Generation

Applied Sciences
Bug reports in open-source projects are often incomplete or low in quality, which reduces maintenance efficiency. To address this issue, we propose AgentReport, a multi-agent pipeline based on large language models (LLMs).
Seojin Choi, Geunseok Yang
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Sustaining CyberWater-VisTrails: A Case Study in Software Upgrades and Reengineering

Information
This study focuses on the process of updating and upgrading a large-scale legacy software system to ensure its compatibility with modern computing environments.
Drew Bieger, Ahmed Sheba, Adham M. Hassan, Sherif Aly, Ranran Chen, Xu Liang, Yao Liang   +6 more
doaj   +1 more source

Measuring Software Modularity Based on Software Networks

Entropy, 2019
Modularity has been regarded as one of the most important properties of a successful software design. It has significant impact on many external quality attributes such as reusability, maintainability, and understandability.
Yiming Xiang, Weifeng Pan, Haibo Jiang, Yunfang Zhu, Hao Li   +4 more
doaj   +1 more source

An empirical study evaluating depth of inheritance on the maintainability of object-oriented software [PDF]

, 1996
This empirical research was undertaken as part of a multi-method programme of research to investigate unsupported claims made of object-oriented technology.
Brooks, A., Daly, J., Miller, J., Roper, M., Wood, M.   +4 more
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Fault Localization Models in Debugging

, 2018
Debugging is considered as a rigorous but important feature of software engineering process. Since more than a decade, the software engineering research community is exploring different techniques for removal of faults from programs but it is quite ...
Alansari, Zainab, Belgaum, Mohammad Riyaz, Miraz, Mahdi H., Soomro, Safeeullah   +3 more
core   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source