Results 51 to 60 of about 67,834 (260)

Finding Relevant Answers in Software Forums [PDF]

open access: yes, 2011
—Online software forums provide a huge amount of valuable content. Developers and users often ask questions and receive answers from such forums. The availability of a vast amount of thread discussions in forums provides ample opportunities for knowledge
David Lo   +6 more
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

open access: yesFEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi   +5 more
wiley   +1 more source

Modeling and Security in Cloud Ecosystems

open access: yesFuture Internet, 2016
Clouds do not work in isolation but interact with other clouds and with a variety of systems either developed by the same provider or by external entities with the purpose to interact with them; forming then an ecosystem.
Eduardo B. Fernandez   +3 more
doaj   +1 more source

Pattern-based software architecture for service-oriented software systems [PDF]

open access: yes, 2010
Service-oriented architecture is a recent conceptual framework for service-oriented software platforms. Architectures are of great importance for the evolution of software systems.
Pahl, Claus, Barrett, Ronan
core  

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Patterns in Teaching Software Development [PDF]

open access: yes, 2004
This paper summarizes the results of Workshop #14 held at ECOOP 2003. The goal of this one-day workshop was to discuss ideas on what and how to teach Software Development. The workshop focused on using patterns and concrete examples. Participants were encouraged to submit a small but concrete project (documentation and the running application).
Erzsébet Angster   +2 more
openaire   +1 more source

Supporting software development through declaratively codified programming patterns

open access: yes, 2002
In current-day software development, programmers often use programming patterns to clarify their intents and to increase the understandability of their programs.
Kim Mens   +6 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

an empirical analysis on distribution patterns of software maintenance effort

open access: yes, 2008
IEEE, IEEE Comp Soc, IEEE Comp Soc TCSE, Reengineering Forum, Shandong CVICSE Middleware, OW2 Consortium, Beijing Simpleware TechDistribution of effort in software engineering process has been the basis for facilitating more reasonable software ...
Qi Li   +7 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

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