Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
THE MODEL AND FUNCTION OF QUALITY ASSESSMENT OF IMPLEMENTATION OF DESIGN PATTERNS [PDF]
Applied Computer Science, 2015 One of the ways of providing high internal software quality (that is a source code) is using design patterns. The article aims at presenting a suggested model which enables one to assess the quality of implementation of design patterns. The model assumes
Rafał WOJSZCZYK
doaj
RipleyGUI: software for analyzing spatial patterns in 3D cell distributions
Frontiers in Neuroinformatics, 2013 The true revolution in the age of digital neuroanatomy is the ability to extensively quantify anatomical structures and thus investigate structure-function relationship in great detail.
Kristin eHansson +3 more
doaj +1 more source
A methodology to assess the impact of design patterns on software quality
, 2012 Context Software quality is considered to be one of the most important concerns of software production teams. Additionally, design patterns are documented solutions to common design problems that are expected to enhance software quality.
Apostolos Ampatzoglou +5 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Weighted Content Similarity Feature for Software Architecture Anti-Patterns Prediction [PDF]
International Journal of Web ResearchAs user needs change frequently over time, software systems must evolve; therefore, increased software complexity inevitably violates software engineering principles. The violations of these principles are called anti-patterns, which differ from bugs and
Somayeh Kalhor +1 more
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
PatEvol – A pattern language for evolution in component-based software architectures [PDF]
, 2013 Modern software systems are prone to a continuous evolution under frequently varying requirements. Architecture-centric software evolution (ACSE) enables change in system structure and behavior while maintaining a global view of software to address ...
Fawad Khaliq (12621274) +8 more
core
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Software patterns to improve knowledge transfer: an experiment. [PDF]
Patterns for software development have been a hot topic for some time within the object-oriented community. Patterns are part of a software engineering problem-solving discipline. It all started with Design Patterns [11], but gradually patterns were used
De Rore, Lotte +3 more
core