Results 91 to 100 of about 2,162,371 (314)
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
Combining Capability Assessment and Value Engineering: a New Two-dimensional Method for Software Process Improvement [PDF]
Journal of Systemics, Cybernetics and Informatics, 2008 During the last decades software process improvement (SPI) has been recognized as a usable possibility to increase the quality of software development. Implemented SPI investments have often indicated increased process capabilities as well. Recently more
Pasi Ojala
doaj
YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma
Molecular Oncology, EarlyView.The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy +9 more
wiley +1 more source
A QUESTIONNAIRE BASED METHOD FOR CMMI LEVEL 2 MATURITY ASSESSMENT
Havacılık ve Uzay Teknolojileri Dergisi, 2009 CMMI has gained widespread acceptance as a viable software process assessment model. In this study, we take up CMMI, and consider the first maturity level or level 2 of the model for companies new to CMMI or just beginning to adopt CMMI in their ...
Fatih Yolcular, Şenol Zafer Erdoğan
doaj
Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Identifying higher capability maturity KPAs of construction organisations; Model refinement through expert interviews [PDF]
Process improvement has been identified as a mechanism of achieving the much needed performance improvements within the construction industry. Despite the concerns of being an industry with unique characteristics, construction has borrowed some process ...
Amaratunga, Dilanthi +2 more
core
A software process improvement solution for small and medium-size enterprises [PDF]
, 2006 The focus of this paper is to outline the main structure of an alternative software process improvement method for small- and medium-size enterprises.
Calvo-Manzano Villalon, Jose Antonio +4 more
core
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
Measuring Process Improvement: Integrating Software Process Assessment With Quality Cost Evaluation [PDF]
, 1995 Matthew P. Neilson, Terry Rout
openalex +1 more source