Results 111 to 120 of about 384,812 (159)

Solid phase synthesis of quinolones

Bioorganic & Medicinal Chemistry Letters, 1999
Solid phase syntheses of ethyl 6-carboxyquinol-4(1H-)-one-3-carboxylate (5) and N-substituted 6-carboxyquinol-4(1H)-one-3-carboxamides 7a-d have been described. Antifilarial in vitro activities of 5,7a-d against Brugia malayi have also been delineated.
S K, Srivastava, W, Haq, P K, Murthy, P M, Chauhan   +3 more
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Solid‐phase synthesis of phosphopeptides

International Journal of Peptide and Protein Research, 1989
We report the solid‐phase synthesis of peptides containing O‐phosphoserine. Coupling was with commercially available Fmoc‐amino acid pentafluorophenyl esters, with base used at each cycle to cleave Fmoc. Phosphorylation of those serine residues left unprotected on the peptide‐resin was achieved with dibenzylphosphochloridate, and finally ...
L, Otvos, I, Elekes, V M, Lee
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Solid-Phase Synthesis of Isoxazolines

Journal of Combinatorial Chemistry, 2002
The polymer-supported synthesis of isoxazolines is described via nitrile oxide intermediates, starting from primary nitroalkanes in a one-pot process.
S, Chandrasekhar, Abbas, Raza, M Venkat, Reddy, J S, Yadav   +3 more
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Solid phase synthesis of benzimidazolones

Tetrahedron Letters, 1996
Abstract An efficient solid phase synthesis of benzimidazoles is described. Polymer bound o-fluoronitroaromatic compound 2 was treated with an amine to give o-nitroaniline derivative 3 . Reduction of 3 with NaBH 4 Cu(acac) 2 followed by cyclization with an aryl imidate and cleavage with TFA gave 5 .
Gary B. Phillips, Guo Ping Wei
openaire   +1 more source

Solid-Phase Synthesis of Phosphopeptides

2013
Phosphopeptides are generally prepared by incorporation of suitable, protected phosphoamino acid derivatives during peptide synthesis using routine coupling protocols. The feasibility of chemical synthesis of phosphorylated peptides by Fmoc-SPPS was greatly enhanced by the introduction of the monobenzyl protecting group for the phosphate group.
Højlys-Larsen, Kim B., Jensen, Knud Jørgen   +1 more
openaire   +3 more sources

Solid‐phase synthesis of H‐ and methylphosphonopeptides

International Journal of Peptide and Protein Research, 1996
We introduce solid‐phase syntheses of H‐ and methylphosphonopeptides, giving access for the first time to a new class of mimics for o‐phosphoamino acids. The model peptides H‐GlyGlyXaaAla‐OH (Xaa = Ser, Thr) were synthesized on a solid‐phase using Fmoc/tBu strategy and HBTU/HOBt activation by incorporation of hydroxyl‐protected serine and threonine. As
Hoffmann, R., Tholey, A., Hoffmann, T., Kalbitzer, H.   +3 more
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Automated Solid-Phase Synthesis of Oligosaccharides

Science, 2001
Traditionally, access to structurally defined complex carbohydrates has been very laborious. Although recent advancements in solid-phase synthesis have made the construction of complex oligosaccharides less tedious, a high level of technical expertise is still necessary to obtain the desired structures.
Plante, O., Palmacci, E., Seeberger, P.
openaire   +3 more sources

Solid-Phase Synthesis of Fullerene-peptides

Journal of the American Chemical Society, 2002
The solid-phase synthesis of peptides (SPPS) containing [60]fullerene-functionalized amino acids is reported. A new amino acid, fulleropyrrolidino-glutamic acid (Fgu), is used for the SPPS of a series of analogues of different length based on the natural Leu(5)-Enkephalin and on cationic antimicrobial peptides.
PANTAROTTO, DAVIDE, BIANCO A, PELLARINI F, TOSSI, ALESSANDRO, GIANGASPERO, ANNA, ZELEZETSKY, IGOR, BRIAND JP, PRATO, MAURIZIO   +7 more
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An Automatic Solid-Phase Synthesis of Peptaibols

The Journal of Organic Chemistry, 2008
An automated approach to peptaibols using microwave-assisted solid-phase peptide synthesis is demonstrated with a combination of HBTU and acid fluoride mediated couplings for normal and alpha,alpha-dialkylated amino acids, respectively. The method is utilized for the automated synthesis of several full-length peptaibols, including alamethicin ...
Hjørringgaard, Claudia Ulrich, Pedersen, Jan Mondrup, Vosegaard, Thomas; id_orcid 0000-0001-5414-4550, Nielsen, Niels Christian, Skrydstrup, Troels   +4 more
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Solid-Phase Synthesis of CD40L Mimetics

Synfacts, 2006
The C3-symmetric molecule has been previously shown to mimic CD40 ligand (CD40L) homotrimers and to display effector functions. This molecule consists of a cyclic hexapeptide core containing the repetition of the D-Ala-L-Lys motif. The side chains of the lysine residues have been modified by appending the CD40L-derived sequence 143Lys-Gly-Tyr-Tyr146 ...
Bianco, Alberto, Fournel, Sylvie, Wieckowski, Sébastien, Hoebeke, Johan, Guichard, Gilles   +4 more
openaire   +2 more sources