Design and Synthesis of a Dual Linker for Solid Phase Synthesis of Oleanolic Acid Derivatives
A hydrophilic amino-terminated poly(ethylene glycol)-type dual linker for solid phase synthesis of oleanolic acid derivatives using trityl chloride resin was designed and synthesized for the first time. Model reactions in both liquid and solid phase were
Shaorong Wang, Weishuo Fang
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A microfluidic oligonucleotide synthesizer [PDF]
De novo gene and genome synthesis enables the design of any sequence without the requirement of a pre-existing template as in traditional genetic engineering methods.
Lee, Cheng-Chung +2 more
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Self-Organized Criticality in Protein Folding Simulations with AMBER Parameters [PDF]
AMBER (Assisted Model Building with Energy Refinement) is a force field that allows for the simulation of proteins. Basic proteins were folded by a Monte-Carlo algorithm parameterized by AMBER on MATLAB. Simulations exhibited self-organized critical (SOC)
Sim, Yura
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Ugi multicomponent reaction to prepare peptide–peptoid hybrid structures with diverse chemical functionalities [PDF]
Monodisperse sequenced peptides and peptoids present unique nano-structures based on their self-assembled secondary and tertiary structures. However, the generation of peptide and peptoid hybrid oligomers in a sequence-defined manner via Ugi ...
Azevedo, Helena S. +12 more
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Lanthanide-Mediated Dephosphorylation Used for Peptide Cleavage during Solid Phase Peptide Synthesis
Lanthanide(III) ions can accelerate the hydrolysis of phosphomonoesters and phosphodiesters in neutral aqueous solution. In this paper, lanthanide-mediated dephosphorylation has been applied in aqueous media as an orthogonal cleavage condition that can ...
Byunghee Yoo, Mark D. Pagel
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Synthesis of Low Loss Lead Free Piezoelectric BNT-BT Ceramic [PDF]
Oxide materials with perovskite structure having the general formula $ABO_3$, form the backbone of the ferroelectrics industry. For a long time, ferroelectric materials have come into widespread use in applications that range in sophistication from ...
Moharana, Chinmayaranjan
core
Automated Synthesis of Oligosaccharides Provides Access to Chemical Tools and Vaccine Candidates
Defined, pure oligosaccharides are important tools for biologists to study the structure and function of carbohydrates in biological systems and to create novel diagnostic and therapeutic approaches.
Lenz Kröck, Peter H. Seeberger
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Synthesis and cellular penetration properties of new phosphonium based cationic amphiphilic peptides [PDF]
A new category of phosphonium based cationic amphiphilic peptides has been developed and evaluated as potential antimicrobial peptides and cell penetrating peptides.
Gannon, Susan +7 more
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Design and Synthesis of a Novel N-(1H-tetrazol-5-yl)methyl Cyclic Peptoid Using Nosyl-protected N-(1-trityl-1H-tetrazol-5-yl)methyl Substituted Glycine [PDF]
: A solid phase synthesis of a cyclic peptoid bearing (1H-tetrazol-5-yl)methyl as N-substituent has been developed employing the monomer approach.
Krishnamurthy, M. +4 more
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Synthesis of high-oxidation Y-Ba-Cu-O phases in superoxygenated thin films
It is known that solid-state reaction in high-pressure oxygen can stabilize high-oxidation phases of Y-Ba-Cu-O superconductors in powder form. We extend this superoxygenation concept of synthesis to thin films which, due to their large surface-to-volume ...
Botton, G. A. +5 more
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