Results 61 to 70 of about 1,857,199 (369)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

The effect of solvent on reactivity of the Li2S–P2S5 system in liquid-phase synthesis of Li7P3S11 solid electrolyte

Scientific Reports, 2021
Synthesis technology for sulfide-based solid electrolytes based on liquid-phase processing has attracted significant interest in relation to achieving the optimal design for all-solid-state batteries.
Hirotada Gamo, Atsushi Nagai, Atsunori Matsuda   +2 more
doaj   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

The Synthesis of cis- and trans-Fused Bicyclic Sugar Amino Acids [PDF]

, 2006
Four isomeric bicyclic sugar amino acids (SAAs) were prepared from an α-acetylenic-C-glucoside by employing a Petasis olefination and a ring-closing metathesis (RCM) as key steps.
Anelli, Billing, Bornaghi, Chakraborty, Chakraborty, Chakraborty, Chatterjee, Cipolla, Coste, Dondoni, Durrat, Edwards, Fleet, Gregar, Grotenbreg, Halcomb, La Ferla, Leeuwenburgh, Leeuwenburgh, Locardi, Locardi, Mayes, Menand, Miller, Montero, Moss, Murray, Peri, Petasis, Raunkjaer, Schwab, Schweizer, Stöckle, Tanaka, Timmer, Trnka, Truffault, van Well   +37 more
core   +2 more sources

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Total Synthesis of Cyclosenegalin A

ChemistryOpen
A Pro‐Gly‐typed cyclopeptide, cyclosenegalin A, was firstly isolated from Annona senegalensis and Annona scleroderma. In this study, we reported synthesis the cycloheptapeptide with a combination of solid‐ and solution‐phase synthetic methods. This study
Anderson Arnold Aloanis, Prof. Tati Herlina, Dr. Ari Hardianto, Prof. Rani Maharani   +3 more
doaj   +1 more source

Exploration of the one-bead one-compound methodology for the design of prolyl oligopeptidase substrates. [PDF]

PLoS ONE, 2009
Here we describe the design, synthesis and evaluation of the first solid-phase substrates for prolyl oligopeptidase (POP), a cytosolic serine peptidase associated with schizophrenia, bipolar affective disorder and related neuropsychiatric disorders. This
Gemma Comellas, Zusanna Kaczmarska, Teresa Tarragó, Meritxell Teixidó, Ernest Giralt   +4 more
doaj   +1 more source

Practical Protocols for Solid-Phase Peptide Synthesis 4.0

Methods and Protocols, 2022
According to the Food and Drug Administration (FDA), there are two kinds of drugs, namely New Chemical Entities (NCEs) and Biologics [...]
Beatriz G. de la Torre, Fernando Albericio   +1 more
doaj   +1 more source

Size dependent phase diagrams of Nickel-Carbon nanoparticles

, 2015
The carbon rich phase diagrams of nickel-carbon nanoparticles, relevant to catalysis and catalytic chemical vapor deposition synthesis of carbon nanotubes, are calculated for system sizes up to about 3 nanometers (807 Ni atoms). A tight binding model for
Amara, Hakim, Bichara, Christophe, Ducastelle, François, Magnin, Yann, Zappelli, Alexandre   +4 more
core   +2 more sources

Peptide-directed crystal growth modification in the formation of ZnO [PDF]

, 2015
Biomolecule-mediated synthesis is fascinating in terms of the level of control and the intricate hierarchical structures of the materials that can be produced.
Liang, M-K, Perry, CC, Roe, MJ, Sola-Rabada, A   +3 more
core   +1 more source