Results 71 to 80 of about 1,178,819 (347)
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Molecules, 2011 Since Gomberg’s discovery of radicals as chemical entities, the interest around them has increased through the years. Nowadays, radical chemistry is used in the synthesis of 75% of all polymers, inevitably establishing a close relationship with Solid ...
Danilo Mirizzi, Maurizio Pulici
doaj +1 more source
Laser solid-phase synthesis of single-atom catalysts
Light: Science & Applications, 2021 Synthesis of Pt single atom catalysts is achieved by one-step laser irradiation of “isolated” H2PtCl6 precursor on graphene oxide, via filtration and freeze-drying sublimation, by simultaneous pyrolysis of the precursor and reduction of graphene oxide.
Yudong Peng +5 more
doaj +1 more source
A facile, inexpensive scalable route to α-methyl cysteine [PDF]
, 2013 A facile, scalable synthesis of α-methyl cysteine with three alternate thiol protecting groups (Trt, Allyl and tBu) is described. The thiol protected amino acids are obtained in 6 steps from L-cysteine ethyl ester and are ideally suited for a range of ...
Hulme, Alison N, Johnston, Heather J
core +1 more source
Solid‐Phase Supports for Oligonucleotide Synthesis [PDF]
Current Protocols in Nucleic Acid Chemistry, 2000 AbstractThis unit begins with a discussion of the advantages and disadvantages of oligonucleotide synthesis using solid supports. The physical and chemical properties of solid‐phase supports are discussed in terms of their suitability for oligonucleotide synthesis. In addition, the unit outlines the properties of linkers used for transient or permanent
openaire +4 more sources
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Synthèse de molécules d'intérêt biologique. Contribution à la synthèse des bastadines [PDF]
Biotechnologie, Agronomie, Société et Environnement, 2010 Synthesis of molecules of biological interest. Contribution to the synthesis of bastadins. The metabolites are a biochemical area whose interest is in constant progression.
Decamps, C. +4 more
doaj
The Synthesis of cis- and trans-Fused Bicyclic Sugar Amino Acids [PDF]
, 2006 Four isomeric bicyclic sugar amino acids (SAAs) were prepared from an α-acetylenic-C-glucoside by employing a Petasis olefination and a ring-closing metathesis (RCM) as key steps.
Anelli +37 more
core +2 more sources
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Solid Phase Formylation of N-Terminus Peptides
Molecules, 2016 Formylation of amino groups is a critical reaction involved in several biological processes including post-translational modification of histones. The addition of a formyl group (CHO) to the N-terminal end of a peptide chain generates biologically active
Anna Lucia Tornesello +2 more
doaj +1 more source