Results 41 to 50 of about 171,924 (301)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Decoherence, control, and encoding of coupled solid-state quantum bits [PDF]

, 2005
In this thesis the decoherence properties, gate performance, control of solid-state quantum bits (qubits), and novel design proposals for solid-state qubits analogous to quantum optics are investigated.
Storcz, Markus J.
core  

Study on bidirectional fluid-solid coupling characteristics of reactor coolant pump under steady-state condition

Nuclear Engineering and Technology, 2019
The AP1000 reactor coolant pump is a vertical shielded-mixed flow pump, is the most important coolant power supply and energy exchange equipment in nuclear reactor primary circuit system, whose steady-state and transient performance affect the safety of ...
Xiuli Wang, Yonggang Lu, Rongsheng Zhu, Qiang Fu, Haoqian Yu, Yiming Chen   +5 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Malfunction Junction

, 2021
aerial view of Malfunction Junction, the Highway 12 Intersectionhttps://scholarsjunction.msstate.edu/ua-photo-collection/5908/thumbnail ...

core  

Rebound Mechanism and Control of the Hard Main Roof in the Deep Mining Roadway in Huainan Mining Area

Shock and Vibration, 2021
Taking the occurrence conditions of the hard main roof in the deep 13-1 coal mining roadway in Huainan mining area as the research object, based on the mechanical parameters of the surrounding rock and the stress state of the main roof obtained by ...
Denghong Chen, Chao Li, Xinzhu Hua, Xiaoyu Lu, Yongqiang Yuan, Chen Li   +5 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Enhanced solid-state reaction synthesis of CdO, SnO, and CdO0·2/SnO0.2 hetero-junction electrode for high-performance energy storage

Chemistry of Inorganic Materials
This study unveils a superior method for energy storage synthesis, employing CdO, SnO, and CdO0·2/SnO0.2 hetero-junction electrodes through enhanced solid-state reaction. The CdO and SnO electrodes with a specific capacitance of 266.66, 191.66, 166.66 ​F/
Waheed Ul Hassan, Ferhan Kaleem, Muhammad Rizwan Mahmood, Dilshaid Hussain, Imtiaz Ahmad, Nawal Alghamdi, Imosobomeh L. Ikhioya   +6 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source