Results 51 to 60 of about 171,924 (301)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
, 2021 picture taken before the intersection of Malfunction Junction--The Stadium is shown.https://scholarsjunction.msstate.edu/ua-photo-collection/3640/thumbnail ...
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Double-Junction Cascaded GaAs-Based Broad-Area Diode Lasers with 132W Continuous Wave Output Power
PhotonicsImproving the output power and efficiency of broad-area diode lasers is a prerequisite for the further development of fiber lasers, solid-state laser industries, and direct semiconductor laser applications.
Jun Wang +10 more
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Small, 2023 AbstractCarbon dots (CDs) are a new class of nanoparticles that gained widespread attention recently because of their easy preparation, water solubility, biocompatibility, and bright luminescence, leading to their integration in various applications. Despite their nm‐scale and proven electron transfer capabilities, the solid‐state electron transport ...
Yuval Toren +2 more
openaire +2 more sources
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
, 2021 The intersection Malfunction Junction is pictured as cars go down the road. A sign above reads, Don\u27t never ever enter.https://scholarsjunction.msstate.edu/ua-photo-collection/2068/thumbnail ...
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The k-junction motif in RNA structure [PDF]
, 2014 The k-junction is a structural motif in RNA comprising a three-way helical junction based upon kink turn (k-turn) architecture. A computer program written to examine relative helical orientation identified the three-way junction of the Arabidopsis TPP ...
Daldrop, Peter +7 more
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Solid immersion lens applications for nanophotonic devices [PDF]
, 2008 Solid immersion lens (SIL) microscopy combines the advantages of conventional microscopy with those of near-field techniques, and is being increasingly adopted across a diverse range of technologies and applications. A comprehensive overview of the state-
O'Connor, John A. +15 more
core +1 more source