Results 221 to 230 of about 7,329 (254)
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Solid-state nanopores and nanopore arrays optimized for optical detection
Nanoscale, 2014Controllable reduction of the local fluorescence around solid-state nanopores and nanopore arrays enables optical recognition of molecular translocations and a route towards massively-parallel detection.
Furat, Sawafta +4 more
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Selective (Bio)Functionalization of Solid-State Nanopores
ACS Applied Materials & Interfaces, 2015We present a method to selectively (bio)functionalize nanoscale features with the same materials chemistry. It was successfully combined with nanosphere lithography to fabricate and functionalize solid-state nanopores with PEG-brushes, supported lipid membranes, and functional proteins over large areas.
Pla-Roca Mateu +3 more
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DNA-functionalized solid state nanopore for biosensing
Nanotechnology, 2010The possible use of nanopores for single DNA molecules biosensing has been demonstrated, but much remains to do in order to develop advanced engineered devices with enhanced stability, and controlled geometry and surface properties. Here we present morphological and electrical characterization of solid state silicon nitride nanopores fabricated by ...
MUSSI, VALENTINA +7 more
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Solid state nanopores for gene expression profiling
Superlattices and Microstructures, 2009Abstract Recently, nanopore technology has been introduced for genome analysis. Here we show results related to the possibility of preparing “engineered solid state nanopores”. The nanopores were fabricated on a suspended Si 3 N 4 membrane by Focused Ion Beam (FIB) drilling and chemically functionalized in order to covalently bind oligonucleotides ...
MUSSI, VALENTINA +7 more
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Data analysis methods for solid-state nanopores
Nanotechnology, 2015We describe a number of techniques for the analysis of solid-state nanopore ionic current traces and introduce a new package of Matlab analysis scripts with GUI front ends. We discuss methods for the detection of the local baseline and propose a new detection algorithm that bypasses some of the classical weaknesses of moving-average detection.
Calin Plesa, Cees Dekker
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Low-frequency noise in solid-state nanopores
Nanotechnology, 2009Low-frequency ionic current noise in solid-state nanopores imposes a limitation on the time resolution achieved in translocation experiments. Recently, this 1/f noise was described as obeying Hooge's phenomenological relation, where the noise scales inversely with the number of charge carriers present.
Smeets, R.M.M. (author) +2 more
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Single-Molecule Analysis with Solid-State Nanopores
Annual Review of Analytical Chemistry, 2019Solid-state nanopores and nanopipettes are an exciting class of single-molecule sensors that has grown enormously over the last two decades. They offer a platform for testing fundamental concepts of stochasticity and transport at the nanoscale, for studying single-molecule biophysics and, increasingly, also for new analytical applications and in ...
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Solid-State Nanopores for Nanoparticle Sensing
Applied Mechanics and Materials, 2014In recent years, single particle detection techniques based on driving nanoparticles through nanoscopic pores with a voltage or pressure had been the subject of numerous studies. Since particles with high charge, such as DNA and proteins, have been widely used for research, there was little information about the translocation behavior of nanosized ...
Lei Wang +3 more
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Circulating tumor DNA in advanced solid tumors: Clinical relevance and future directions
Ca-A Cancer Journal for Clinicians, 2021Michael L Cheng +2 more
exaly
Current and future cancer staging after neoadjuvant treatment for solid tumors
Ca-A Cancer Journal for Clinicians, 2021James D Brierley Mb, Frcp +1 more
exaly