Results 231 to 240 of about 22,049 (261)

Fabrication of solid-state nanopores

Nanotechnology, 2022
Abstract Nanopores are valuable single-molecule sensing tools that have been widely applied to the detection of DNA, RNA, proteins, viruses, glycans, etc. The prominent sensing platform is helping to improve our health-related quality of life and accelerate the rapid realization of precision medicine.
Kabin Lin, Chen Chen, Congsi Wang, Peiyuan Lian, Yan Wang, Song Xue, Jingjie Sha, Yunfei Chen   +7 more
openaire   +2 more sources

Rescalable solid-state nanopores

AIP Conference Proceedings, 2017
Nanopores in 10–30 nm thickness Si4N3 membranes were milled using Ga+ ions. Dose dependence of the hole diameter and shape was established and explained as resulting from the intensity distribution of the focused ion beam. The initial diameter of the milled pore is dependent on the full-width half-maximum of the axial portion of the beam, whereas shape
Armandas Balčytis, Cleménce Briosne-Fréjaville, Adrien Mau, Xijun Li, Saulius Juodkazis   +4 more
openaire   +1 more source

Microfluidic multiplexing of solid-state nanopores

Journal of Physics: Condensed Matter, 2017
Although solid-state nanopores enable electronic analysis of many clinically and biologically relevant molecular structures, there are few existing device architectures that enable high-throughput measurement of solid-state nanopores. Herein, we report a method for microfluidic integration of multiple solid-state nanopores at a high density of one ...
Tarun Jain, Benjamin C Rasera, Ricardo Jose S Guerrero, Jong-Min Lim, Rohit Karnik   +4 more
openaire   +2 more sources

Solid-State Nanopore Technologies for Nanopore-Based DNA Analysis

Nanomedicine, 2007
Nanopore-based DNA analysis is a new single-molecule technique that involves monitoring the flow of ions through a narrow pore, and detecting changes in this flow as DNA molecules also pass through the pore. It has the potential to carry out a range of laboratory and medical DNA analyses, orders of magnitude faster than current methods.
Ken, Healy, Birgitta, Schiedt, Alan P, Morrison   +2 more
openaire   +2 more sources

Solid-state nanopores and nanopore arrays optimized for optical detection

Nanoscale, 2014
Controllable reduction of the local fluorescence around solid-state nanopores and nanopore arrays enables optical recognition of molecular translocations and a route towards massively-parallel detection.
Furat, Sawafta, Bason, Clancy, Autumn T, Carlsen, Martin, Huber, Adam R, Hall   +4 more
openaire   +2 more sources

Selective (Bio)Functionalization of Solid-State Nanopores

ACS Applied Materials & Interfaces, 2015
We present a method to selectively (bio)functionalize nanoscale features with the same materials chemistry. It was successfully combined with nanosphere lithography to fabricate and functionalize solid-state nanopores with PEG-brushes, supported lipid membranes, and functional proteins over large areas.
Pla-Roca Mateu, Isa Lucio, Kumar Karthik, Reimhult Erik   +3 more
openaire   +2 more sources

DNA-functionalized solid state nanopore for biosensing

Nanotechnology, 2010
The possible use of nanopores for single DNA molecules biosensing has been demonstrated, but much remains to do in order to develop advanced engineered devices with enhanced stability, and controlled geometry and surface properties. Here we present morphological and electrical characterization of solid state silicon nitride nanopores fabricated by ...
MUSSI, VALENTINA, P. Fanzio, REPETTO, LUCA, FIRPO, GIUSEPPE, P. Scaruffi, S. Stigliani, G. P. Tonini, VALBUSA, UGO   +7 more
openaire   +4 more sources

Solid state nanopores for gene expression profiling

Superlattices and Microstructures, 2009
Abstract Recently, nanopore technology has been introduced for genome analysis. Here we show results related to the possibility of preparing “engineered solid state nanopores”. The nanopores were fabricated on a suspended Si 3 N 4 membrane by Focused Ion Beam (FIB) drilling and chemically functionalized in order to covalently bind oligonucleotides ...
MUSSI, VALENTINA, P. Fanzio, REPETTO, LUCA, FIRPO, GIUSEPPE, VALBUSA, UGO, P. Scaruffi, S. Stigliani, G. Tonini   +7 more
openaire   +2 more sources

Data analysis methods for solid-state nanopores

Nanotechnology, 2015
We describe a number of techniques for the analysis of solid-state nanopore ionic current traces and introduce a new package of Matlab analysis scripts with GUI front ends. We discuss methods for the detection of the local baseline and propose a new detection algorithm that bypasses some of the classical weaknesses of moving-average detection.
Calin Plesa, Cees Dekker
openaire   +2 more sources

Low-frequency noise in solid-state nanopores

Nanotechnology, 2009
Low-frequency ionic current noise in solid-state nanopores imposes a limitation on the time resolution achieved in translocation experiments. Recently, this 1/f noise was described as obeying Hooge's phenomenological relation, where the noise scales inversely with the number of charge carriers present.
Smeets, R.M.M. (author), Dekker, N.H. (author), Dekker, C. (author)   +2 more
openaire   +4 more sources