Results 61 to 70 of about 71,435 (301)

Formulation and Characterization of Phytostanol Ester Solid Lipid Nanoparticles for the Management of Hypercholesterolemia: An ex vivo Study

International Journal of Nanomedicine, 2021
Sony Chandi Shrestha,1,2 Kebreab Ghebremeskel,1 Kenneth White,1 Caterina Minelli,2 Ihab Tewfik,3 Panna Thapa,4 Sundus Tewfik5 1School of Human Sciences, London Metropolitan University, London, UK; 2Surface Technology, National Physical Laboratory, London,
Shrestha SC, Ghebremeskel K, White K, Minelli C, Tewfik I, Thapa P, Tewfik S   +6 more
doaj  

Anticancer Effects of Resveratrol-Loaded Solid Lipid Nanoparticles on Human Breast Cancer Cells

Molecules, 2017
In this study, resveratrol-loaded solid lipid nanoparticles (Res-SLNs) were successfully designed to treat MDA-MB-231 cells. The Res-SLNs were prepared using emulsification and low-temperature solidification method.
Wenrui Wang, Lingyu Zhang, Tiantian Chen, Wen Guo, Xunxia Bao, Dandan Wang, Baihui Ren, Haifeng Wang, Yu Li, Yueyue Wang, Sulian Chen, Baoding Tang, Qingling Yang, Changjie Chen   +13 more
doaj   +1 more source

Biophysicochemical interaction of a clinical pulmonary surfactant with nano-alumina

, 2015
We report on the interaction of pulmonary surfactant composed of phospholipids and proteins with nanometric alumina (Al2O3) in the context of lung exposure and nanotoxicity.
Berret, J. -F., Borgne, R. Le, Mousseau, F., Seyrek, E.   +3 more
core   +4 more sources

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source

Development and optimization of solid lipid nanoparticle formulation for ophthalmic delivery of chloramphenicol using a Box-Behnken design

International Journal of Nanomedicine, 2011
Jifu Hao1, Xinsheng Fang2, Yanfang Zhou3, Jianzhu Wang1, Fengguang Guo1, Fei Li1, Xinsheng Peng31College of Pharmacy, Taishan Medical University, Taian, PR China; 2Agronomy Department of Shandong Agriculture University, Taian, PR China; 3School of ...
Hao JF, Fang XS, Zhou YF, Wang JZ, Guo FG, Li F, Peng XS   +6 more
doaj  

Formulation of the novel structure curcumin derivative–loaded solid lipid nanoparticles: synthesis, optimization, characterization and anti-tumor activity screening in vitro

Drug Delivery, 2022
This study investigated the effect of structural modification of Curcumin (CU) combined with the solid lipid nanoparticles (SLN) drug delivery system on anti-tumor activity in vitro.
Ke Li, Chao Pi, Jie Wen, Yingmeng He, Jiyuan Yuan, Hongping Shen, Wenmei Zhao, Mingtang Zeng, Xinjie Song, Robert J. Lee, Yumeng Wei, Ling Zhao   +11 more
doaj   +1 more source

Tailoring the Properties of Functional Materials With N‐Oxides

Advanced Functional Materials, EarlyView.
The properties of materials bearing N‐oxide groups are often dominated by the polar N+─O− bond. It provides hydrophilicity, selective ion‐binding, electric conductivity, or antifouling properties. Many of the underlying mechanisms have only recently been discovered, and the interest in N‐oxide materials is rapidly growing.
Timo Friedrich, Michelle Kobus, Shirin Mesgarha, Erica Moretto, Laurens Grosche, Wolfgang Maison   +5 more
wiley   +1 more source

Preparation, Characterization and Pharmacokinetics of Tolfenamic Acid-Loaded Solid Lipid Nanoparticles

Pharmaceutics, 2022
The clinical use of nonsteroidal anti-inflammatory drugs is limited by their poor water solubility, unstable absorption, and low bioavailability.
Wei Xu, Zhaoyou Deng, Yifei Xiang, Dujuan Zhu, Dandan Yi, Yihao Mo, Yu Liu, Lanqian Qin, Ling Huang, Bingjie Wan, Liqin Wu, Xin Feng, Jiakang He   +12 more
doaj   +1 more source

Spleen‐Targeting Biomimetic Hybrid Nanocarriers for Systemic Immune Reprogramming in Colitis: RBC Membrane Vesicle‐Fused Lipid Nanoparticles

Advanced Functional Materials, EarlyView.
A spleen‐targeting hybrid nanoplatform (RBCMV‐LNP‐RP) harnessing erythrophagocytosis mimics senescent red blood cell clearance to achieve spleen‐specific delivery of rapamycin. This biomimetic system enables selective accumulation in splenic macrophages, orchestrating systemic immune reprogramming and promoting mucosal healing in an inflammatory bowel ...
Jun Kwon, Hee Su Sohn, Jong Sang Yoon, So Won Jeon, Hee Gyeong Ko, Min‐Ho Kang, Jisun Lee, Jae‐Hwan Nam, Louis T. Merriam, Edy Y. Kim, Han Young Kim   +10 more
wiley   +1 more source

Tetrahydrocurcumin Lipid Nanoparticle Based Gel Promotes Penetration into Deeper Skin Layers and Alleviates Atopic Dermatitis in 2,4-Dinitrochlorobenzene (DNCB) Mouse Model

Nanomaterials, 2022
Treatment of atopic dermatitis (AD) is challenging due to its complex pathophysiology. Tetrahydrocurcumin (THC) a polyphenolic, colorless compound that is more polar than curcumin.
Komal Saini, Nancy Modgill, Kamalinder K. Singh, Vandita Kakkar   +3 more
doaj   +1 more source