Results 51 to 60 of about 899,512 (307)

Quantification of voriconazole in plasma by liquid chromatography-tandem mass spectrometry [PDF]

, 2005
A convenient liquid chromatography-tandem mass spectrometry method for the quantification of the triazole antifungal agent voriconazole in plasma samples is described. Fenbuconazole is used as an internal standard.
Boyd, Denning, Dooley, Gage, Glasmacher, Hyland, Johnson, Keevil, Ozawa, Pennick, Potoski, Roffey, Stopher, Trifilio, Vogeser, Vogeser, Vogeser   +16 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Myopes have significantly higher serum melatonin concentrations than non-myopes [PDF]

, 2017
Purpose Experimental animal models of myopia demonstrate that higher melatonin (Mel) and lower dopamine (DA) concentrations actively promote axial elongation.
Ackermann, Atkinson, Ayaki, Baba, Barnard, Beck-Friis, Benavente-Pérez, Benloucif, Berg, Bertolet, Besharse, Breslin, Brown, Cahill, Chang, Chiba, Chua, Delgado, Dong, Eisenberg, Fan, Freedman, Guo, Hammond, He, Hua, Huang, Huang, Hughes, Iuvone, Jee, Kivelä, Lanyon, Logan, Lu, Mallen, Mao, Martin, McCullough, Megaw, Megaw, Nickla, Nickla, Ohngemach, Panda, Pendrak, Rada, Rao, Riefahn, Rohrer, Rose, Rudnicka, Sankaridurg, Skene, Stone, Stone, Stormann, Tosini, Trier, Verkicharla, Wahl, Wallman, Wang, Weiss, Wiechmann, Wiechmann, Wilson, Witkovsky, Wu, Xu, Zhang   +70 more
core   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Multiplexed Colorimetric Solid-Phase Extraction [PDF]

Multiplexed colorimetric solid-phase extraction (MC-SPE) is an extension of colorimetric solid-phase extraction (C-SPE) an analytical platform that combines colorimetric reagents, solid phase extraction, and diffuse reflectance spectroscopy to quantify ...
Fritz, James S., Gazda, Daniel B., Porter, Marc D.   +2 more
core   +1 more source

Rapid, Low Level Determination of Silver(I) in Drinking Water by Colorimetric–solid-phase Extraction [PDF]

, 2003
A rapid, highly sensitive two-step procedure for the trace analysis of silver(I) is described. The method is based on: (1) the solid-phase extraction (SPE) of silver(I) from a water sample onto a disk impregnated with a silver-selective colorimetric ...
Arena, Matteo P., Fritz, James S., Porter, Marc D.   +2 more
core   +1 more source

Сорбционное концентрирование следовых количеств хлорамфеникола на поверхности силикагеля, модифицированного октадецильнимы группами [PDF]

, 2016
Проблематика. Хлорамфенікол (ХЛ) – антибіотик широкого спектра дії, використовується у різних галузях ветеринарії і може накопичуватись у продуктах харчування тваринного походження.
Ivanova, O. M., Sikolenko, T. V., Иванова, О. М., Сиколенко, Т. В., Сіколенко, Таїсія Володимирівна, Іванова, Ольга Михайлівна   +5 more
core   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Micelle assisted thin-film solid phase microextraction: a new approach for determination of quaternary ammonium compounds in environmental samples [PDF]

, 2014
Determination of quaternary ammonium compounds (QACs) often is considered to be a challenging undertaking owing to secondary interactions of the analytes’ permanently charged quaternary ammonium head or hydrophobic tail with the utilized lab-wares ...
Boyaci, Ezel, Pawliszyn, Janusz
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source