Results 51 to 60 of about 303,562 (310)

Novas estratégias de otimização para a técnica de SPME e SPME com recobrimento internamente refrigerado [PDF]

, 2012
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas, Programa de Pós-Graduação em Química, Florianópolis, 2011Esta Tese apresenta três novas estratégias de otimização, sendo duas aplicadas à técnica de ...
Martendal, Edmar
core  

Quantification of voriconazole in plasma by liquid chromatography-tandem mass spectrometry [PDF]

, 2005
A convenient liquid chromatography-tandem mass spectrometry method for the quantification of the triazole antifungal agent voriconazole in plasma samples is described. Fenbuconazole is used as an internal standard.
Spöhrer, Ute, Schiel, Xaver, Vogeser, Michael   +2 more
core   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Supercritical fluid extraction of veterinary drug residues from meat [PDF]

, 1999
End of project ReportExtraction is a key step in the analysis of food samples for residues of veterinary drugs. Over the last ten years there has been increasing interest in alternatives to the use of organic solvents for sample extraction.
O'Keeffe, Mandy J., O'Keeffe, Michael
core  

Recent Advance in the Sample Pretreatments for Drug Analysis in Zebrafish

Pharmaceuticals
Zebrafish, as an emerging model organism, are widely used in in vivo pharmacodynamic and pharmacokinetic studies. Unlike direct chemical analyses that require no sample preparation, most biological samples must undergo preprocessing steps—procedures that
Ting Wang, Chuyu Wang, Mingjing Luo, Xinyu Wang, Yiwen Chen, Zhi Yang, Guang Hu, Weikang Liu   +7 more
doaj   +1 more source

Optimization of Solid Phase Microextraction Conditions for Volatile Components of Foods by Using Response Surface Methodology

Turkish Journal of Agriculture: Food Science and Technology, 2017
High vacuum steam distillation, simultaneous distillation extraction, steam distillation, purge and trap methods are used for sample preparation in volatile component analysis. Since these methods are difficult and costly to implement, these methods have
Ceyda Dadalı, Yeşim Elmacı Elmacı
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

New techniques of on-line biological sample processing and their application in the field of biopharmaceutical analysis

Acta Pharmaceutica Sinica B, 2016
Biological sample pretreatment is an important step in biological sample analysis. Due to the diversity of biological matrices, the analysis of target substances in these samples presents significant challenges to sample processing.
Jie Peng, Fang Tang, Rui Zhou, Xiang Xie, Sanwang Li, Feifan Xie, Peng Yu, Lingli Mu   +7 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Analysis of some B-adrenergic agonists in biological matrices after evaluation of various extraction methodologies and determination procedures [PDF]

, 1994
Biological sample clean-up procedures were evaluated for the extraction of a range of /3-agonists. Once extracted the compounds were determined by immunoassay, electrochemical techniques and supercritical fluid chromatography (SFC).
Boyd, Damien Thomas
core