Results 151 to 160 of about 199,414 (326)

Investigating the chemistry of lipoyl synthase [PDF]

, 2008
The radical SAM protein lipoyl synthase (LipA) is essential for lipoic acid biosynthesis via sulfur insertions into the unactivated C6 and C8 centres of a protein-bound octanoyl group.
Douglas, Paul
core  

Mechanistic Study of Diketopiperazine Formation during Solid-Phase Peptide Synthesis of Tirzepatide. [PDF]

ACS Omega, 2022
Wang J, Berglund MR, Braden T, Embry MC, Johnson MD, Groskreutz SR, Sayyed FB, Tsukanov SV, White TD, Jalan A, Seibert KD, Kopach ME.   +11 more
europepmc   +1 more source

The Host Cell Factor Phosphatase‐2A Subunit PR130 Restricts Replication of Herpes Simplex Virus Type‐1

Advanced Science, EarlyView.
Molecular, genetic, virological, and biochemical analysis in combination with global proteome and phosphoproteome profiling and functional assays were applied to study the role of PR130 in the context of HSV‐1 replication. The observations reveal that host‐intrinsic mechanisms regulate HSV‐1 replication and highlight PR130 as a susceptibility factor of
Johannes Jungwirth, Christoph F. Jacob, Alexandra Nguyen, Mandy Beyer, Andreas O. Mieland, Mario Dejung, Jia‐Xuan Chen, Walburgis Brenner, Christina Ehrhardt, Andreas Henke, Oliver H. Krämer   +10 more
wiley   +1 more source

Label-Free Imaging of Solid-Phase Peptide Synthesis Products and Their Modifications Tethered in Microspots Using Time-of-Flight Secondary Ion Mass Spectrometry. [PDF]

Int J Mol Sci, 2023
Schmidt D, Maier J, Bernauer H, Nesterov-Mueller A.   +3 more
europepmc   +1 more source

An Implantable Optogenetics‐Engineered Hydrogel for Amelioration of Rheumatoid Arthritis through Light‐Controlled Metabolic Reprogramming of Synovial Macrophages

Advanced Science, EarlyView.
An implantable hydrogel is designed to enable in situ and on‐demand secretion of GLP‐1 in synovium through blue light irradiation to activate GLP‐1R/HK2/VDAC1 pathway for upregulating tricarboxylic acid cycle and oxidative phosphorylation in macrophage, facilitating tissue repair and bone erosion recovery.
Dahai Hu, Yaru Sun, Qi Lu, Yi Zhang, Jieruo Li, Huige Hou, Huajun Wang, Hui Tang, Yunsong Zhang, Xiaofei Zheng, Qingsong Mei   +10 more
wiley   +1 more source

Synthesis of cyclic peptide natural products and inhibitors of histone modifying enzymes [PDF]

, 2011
Natural products have been the source of numerous leads for several drugs. As these natural products are often isolated in small quantities, it is necessary to produce them synthetically to allow testing for biological activity.
Benelkebir, Hanae
core  

Light‐Imprinted Chirality in Nanomaterials: From Principles to Applications

Advanced Science, EarlyView.
Light‐induced chirality represents a transformative paradigm for fabricating chiral nanostructures. This review provides a comprehensive framework encompassing light‐based strategies for imprinting and tuning chirality in nanomaterials, which guides researchers in harnessing light to create next‐generation functional materials.
Xinru Jin, Emiliano Cortés, Alexander O. Govorov, Tao Ding   +3 more
wiley   +1 more source

Amino-Li-Resin-A Fiber Polyacrylamide Resin for Solid-Phase Peptide Synthesis. [PDF]

Polymers (Basel), 2022
Akintayo DC, de la Torre BG, Li Y, Albericio F.   +3 more
europepmc   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Harnessing Phase Separation for the Development of High‐Performance Hydrogels

Advanced Science, EarlyView.
ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao, Yiming Ma, Baihao Shao, Molly M. Stevens   +3 more
wiley   +1 more source