Recyclable hypervalent-iodine-mediated solid-phase peptide synthesis and cyclic peptide synthesis [PDF]
Beilstein Journal of Organic Chemistry, 2018 The system of the hypervalent iodine(III) reagent FPID and (4-MeOC6H4)3P was successfully applied to solid-phase peptide synthesis and cyclic peptide synthesis.
Dan Liu, Ya-Li Guo, Jin Qu, Chi Zhang
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Total wash elimination for solid phase peptide synthesis [PDF]
Nature Communications, 2023 We present a process for solid phase peptide synthesis (SPPS) that completely eliminates all solvent intensive washing steps during each amino acid addition cycle.
Jonathan M. Collins +6 more
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Practical Protocols for Solid-Phase Peptide Synthesis 4.0 [PDF]
Methods and Protocols, 2022 According to the Food and Drug Administration (FDA), there are two kinds of drugs, namely New Chemical Entities (NCEs) and Biologics [...]
Beatriz G. de la Torre +1 more
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Dipropyleneglycol Dimethylether, New Green Solvent for Solid-Phase Peptide Synthesis: Further Challenges to Improve Sustainability in the Development of Therapeutic Peptides [PDF]
Pharmaceutics, 2023 In recent years, peptides have gained more success as therapeutic compounds. Nowadays, the preferred method to obtain peptides is solid-phase peptide synthesis (SPPS), which does not respect the principles of green chemistry due to the large number of ...
Giovanni Vivenzio +5 more
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Dipropylamine for 9-Fluorenylmethyloxycarbonyl (Fmoc) Deprotection with Reduced Aspartimide Formation in Solid-Phase Peptide Synthesis. [PDF]
ACS Omega, 2023 Herein, we report dipropylamine (DPA) as a fluorenylmethyloxycarbonyl (Fmoc) deprotection reagent to strongly reduce aspartimide formation compared to piperidine (PPR) in high-temperature (60 °C) solid-phase peptide synthesis (SPPS).
Personne H +3 more
europepmc +2 more sources
Rhodiasolv PolarClean – a greener alternative in solid-phase peptide synthesis
Green Chemistry Letters and Reviews, 2021 PolarClean, a green solvent prepared through the valorization of a byproduct of Nylon-66 manufacturing, shows an excellent capacity to dissolve all Fmoc-amino acids and key coupling reagents and additives.
Ashish Kumar +3 more
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Safety-Catch Linkers for Solid-Phase Peptide Synthesis [PDF]
MoleculesSolid-phase peptide synthesis (SPPS) is the preferred strategy for synthesizing most peptides for research purposes and on a multi-kilogram scale. One key to the success of SPPS is the continual evolution and improvement of the original method proposed ...
Sikabwe Noki +2 more
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Evaluation of greener solvents for solid-phase peptide synthesis
Green Chemistry Letters and Reviews, 2021 Polar aprotic solvents such as N,N-Dimethylformamide (DMF), N-methyl-2-pyrrolidone (NMP), N,N’-dimethylacetamide (DMAc) and chlorinated solvent such dichloromethane (DCM) are the most widely used solvents for Fmoc solid-phase peptide synthesis (SPPS ...
Katarzyna Wegner +4 more
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Sustainable Ultrasound-Assisted Solid-Phase peptide synthesis (SUS-SPPS): Less Waste, more efficiency [PDF]
Ultrasonics SonochemistryThe integration of low-frequency ultrasound with Solid-Phase Peptide Synthesis (SPPS) was explored to establish a Sustainable Ultrasound-assisted Solid-Phase Peptide Synthesis (SUS-SPPS) method.
Salvatore Mottola +8 more
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A Photolabile Carboxyl Protecting Group for Solid Phase Peptide Synthesis [PDF]
ChemistryOpen, 2021 A new kind of photolabile protecting group (PLPG) for carboxyl moieties was designed and synthesized as the linker between resin and peptide. This group can be used for the protection of amino acid carboxyl groups.
Hongpeng Yang +8 more
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