Results 11 to 20 of about 124,083 (150)

Late-stage peptide C–H alkylation for bioorthogonal C–H activation featuring solid phase peptide synthesis [PDF]

Nature Communications, 2019
Palladium-catalyzed late-stage diversification of structurally complex peptides has major shortcomings. Here, the authors developed a ruthenium-catalyzed C–H alkylations of peptides allowing for fluorescence labeling, late-stage diversifications and ...
Alexandra Schischko, Nikolaos Kaplaneris, Torben Rogge, Giedre Sirvinskaite, Jongwoo Son, Lutz Ackermann   +5 more
doaj   +2 more sources

Synthetic Evaluation of Standard and Microwave-Assisted Solid Phase Peptide Synthesis of a Long Chimeric Peptide Derived from Four Plasmodium falciparum Proteins [PDF]

Molecules, 2018
An 82-residue-long chimeric peptide was synthesised by solid phase peptide synthesis (SPPS), following the Fmoc protocol. Microwave (MW) radiation-assisted synthesis was compared to standard synthesis using low loading (0.20 mmol/g) of polyethylene ...
Yahson F. Varela, Magnolia Vanegas Murcia, Manuel Elkin Patarroyo   +2 more
doaj   +2 more sources

Solid‐Phase Synthesis of Lipidated Peptides [PDF]

Chemistry – A European Journal, 2005
AbstractA new flexible and efficient methodology for the solid‐phase synthesis of lipidated peptides has been developed. The approach is based on the use of previously synthesized building blocks and overcomes the limitations of previously reported methods, since long doubly lipidated peptides can be synthesized by using this route. Furthermore, it was
Lumbierres, M., Palomo, J., Kragol, G., Roehrs, S., Müller, O., Waldmann, H.   +5 more
openaire   +9 more sources

Magnetic nanoparticle-based solid phase peptide synthesis and the synchronous detection of their biological activity

Materials Today Advances, 2021
The solid-phase peptide synthesis (SPPS) strategy, as the main procedure of peptide manufacturing, has a profound impact on the research of peptides.
D. Luo, P. Wang, Q. Zheng, R. Han, C. Shi, L. Wang, Y. Hong, Y. Liu, Y. Sha   +8 more
doaj   +1 more source

Rhodiasolv PolarClean – a greener alternative in solid-phase peptide synthesis

Green Chemistry Letters and Reviews, 2021
PolarClean, a green solvent prepared through the valorization of a byproduct of Nylon-66 manufacturing, shows an excellent capacity to dissolve all Fmoc-amino acids and key coupling reagents and additives.
Ashish Kumar, Anamika Sharma, Beatriz G. de la Torre, Fernando Albericio   +3 more
doaj   +1 more source

First total synthesis of hoshinoamide A

Beilstein Journal of Organic Chemistry, 2021
Hoshinoamides A, B and C, linear lipopeptides, were isolated from the marine cyanobacterium Caldora penicillata, with potent antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum.
Haipin Zhou, Zihan Rui, Yiming Yang, Shengtao Xu, Yutian Shao, Long Liu   +5 more
doaj   +1 more source

Fragment synthesis of disulfide-containing peptides

MethodsX, 2020
A new strategy for solid phase peptide synthesis in the fragment synthesis based on the use of 2-Cl-trityl resin as carrier to obtain protected peptide-resin and Rink Amide Resin, HOBT/HBTU or PyBOP/DIPEA or HATU/DIPEA as the coupling method is described.
Yuxuan Dai, Na Yue, Wenlong Huang, Hai Qian   +3 more
doaj   +1 more source

Deprotection Reagents in Fmoc Solid Phase Peptide Synthesis: Moving Away from Piperidine? [PDF]

Molecules, 2016
Luna OF, Gomez J, Cárdenas C, Albericio F, Marshall SH, Guzmán F.   +5 more
europepmc   +2 more sources

Solid Phase versus Solution Phase Synthesis of Heterocyclic Macrocycles

Molecules, 2013
Comparing a solution phase route to a solid phase route in the synthesis of the cytotoxic natural product urukthapelstatin A (Ustat A) confirmed that a solid phase method is superior.
Shelli R. McAlpine, Seong Jong Kim
doaj   +1 more source

5-Amino-3-methyl-Isoxazole-4-carboxylic Acid as a Novel Unnatural Amino Acid in the Solid Phase Synthesis of α/β-Mixed Peptides

Molecules, 2022
The hybrid peptides consisting of α and β-amino acids show great promise as peptidomimetics that can be used as therapeutic agents. Therefore, the development of new unnatural amino acids and the methods of their incorporation into the peptide chain is ...
Urszula Bąchor, Agnieszka Lizak, Remigiusz Bąchor, Marcin Mączyński   +3 more
doaj   +1 more source