Results 11 to 20 of about 132,649 (294)
Beilstein Journal of Organic Chemistry, 2008 A mild synthetic method for N-formyl-Met-Leu-Phe-OH (1) is described. After Fmoc solid phase peptide synthesis, on-bead formylation and HPLC purification, more than 30 mg of the fully 13C/15N-labelled tripeptide 1 could be isolated in a typical batch ...
Sven T. Breitung +5 more
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Late-stage peptide C–H alkylation for bioorthogonal C–H activation featuring solid phase peptide synthesis [PDF]
Nature Communications, 2019 Palladium-catalyzed late-stage diversification of structurally complex peptides has major shortcomings. Here, the authors developed a ruthenium-catalyzed C–H alkylations of peptides allowing for fluorescence labeling, late-stage diversifications and ...
Alexandra Schischko +5 more
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Synthetic Evaluation of Standard and Microwave-Assisted Solid Phase Peptide Synthesis of a Long Chimeric Peptide Derived from Four Plasmodium falciparum Proteins [PDF]
Molecules, 2018 An 82-residue-long chimeric peptide was synthesised by solid phase peptide synthesis (SPPS), following the Fmoc protocol. Microwave (MW) radiation-assisted synthesis was compared to standard synthesis using low loading (0.20 mmol/g) of polyethylene ...
Yahson F. Varela +2 more
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Fmoc Solid-Phase Peptide Synthesis
, 2015 Synthetic peptides are important as drugs and in research. Currently, the method of choice for producing these compounds is solid-phase peptide synthesis. Here, we describe the scope and limitations of Fmoc solid-phase peptide synthesis.
Hansen, Paul Robert, Oddo, Alberto
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, 2023 Introduction: A peptide is a molecule that consists of two or more amino acids and a chain of peptides makes up a protein. Peptides and proteins are fundamental to the human body and have many different functions depending on their sequence.
Ham, Seung +3 more
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Solid‐Phase Synthesis of Lipidated Peptides [PDF]
Chemistry – A European Journal, 2005 AbstractA new flexible and efficient methodology for the solid‐phase synthesis of lipidated peptides has been developed. The approach is based on the use of previously synthesized building blocks and overcomes the limitations of previously reported methods, since long doubly lipidated peptides can be synthesized by using this route. Furthermore, it was
Lumbierres, M. +5 more
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Materials Today Advances, 2021 The solid-phase peptide synthesis (SPPS) strategy, as the main procedure of peptide manufacturing, has a profound impact on the research of peptides.
D. Luo +8 more
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First total synthesis of hoshinoamide A
Beilstein Journal of Organic Chemistry, 2021 Hoshinoamides A, B and C, linear lipopeptides, were isolated from the marine cyanobacterium Caldora penicillata, with potent antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum.
Haipin Zhou +5 more
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Fragment synthesis of disulfide-containing peptides
MethodsX, 2020 A new strategy for solid phase peptide synthesis in the fragment synthesis based on the use of 2-Cl-trityl resin as carrier to obtain protected peptide-resin and Rink Amide Resin, HOBT/HBTU or PyBOP/DIPEA or HATU/DIPEA as the coupling method is described.
Yuxuan Dai +3 more
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An amalgamation of solid phase peptide synthesis and ribosomal peptide synthesis [PDF]
Peptide Science, 2008 AbstractExpressed protein ligation (EPL) is a protein semisynthesis technique that allows the site‐specific introduction of unnatural amino acids and biophysical probes into proteins. In the present study, we illustrate the utility of the approach through the generation of two semisynthetic proteins bearing spectroscopic probes. Dihydrofolate reductase
Jennifer J, Ottesen +3 more
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