Results 321 to 330 of about 1,859,179 (392)

Solid-Phase Organometallic Synthesis

Chemistry - A European Journal, 2001
A solid-phase synthesis approach for a class of molybdenum carbonyl complexes has been developed. The system can be used to perform metal-complexation, ligand substitution reactions and oxidative eliminations on the solid phase and to cleave the final complexes under mild and selective conditions.
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Solid phase synthesis of quinolones

Bioorganic & Medicinal Chemistry Letters, 1999
Solid phase syntheses of ethyl 6-carboxyquinol-4(1H-)-one-3-carboxylate (5) and N-substituted 6-carboxyquinol-4(1H)-one-3-carboxamides 7a-d have been described. Antifilarial in vitro activities of 5,7a-d against Brugia malayi have also been delineated.
S K, Srivastava, W, Haq, P K, Murthy, P M, Chauhan   +3 more
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Solid phase synthesis of praziquantel

Tetrahedron Letters, 2006
The first solid phase synthesis of the important anthelmintic praziquantel is described. The synthesis is rapid and efficient. The method may be extended to the synthesis of libraries of urgently needed replacements for this drug.
M. Todd, S. El-Fayyoumy, W. Mansour
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Convergent solid-phase peptide synthesis

Tetrahedron, 1993
The solid-phase synthesis, photolytic detachment from the solid support and purification in solution, of a fully-protected octapeptide containing a methionine residue (protected as the sulphoxide) is described. Protection of methionine in this manner avoids problems associated with the oxidation of this residue during the photolysis.
F, Albericio, P, Lloyd-Williams, E, Giralt   +2 more
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Solid‐phase synthesis of phosphopeptides

International Journal of Peptide and Protein Research, 1989
We report the solid‐phase synthesis of peptides containing O‐phosphoserine. Coupling was with commercially available Fmoc‐amino acid pentafluorophenyl esters, with base used at each cycle to cleave Fmoc. Phosphorylation of those serine residues left unprotected on the peptide‐resin was achieved with dibenzylphosphochloridate, and finally ...
L, Otvos, I, Elekes, V M, Lee
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Solid phase synthesis of oligosaccharides

Tetrahedron Letters, 1996
Abstract An efficient and stereocontrolled solid-phase chemical synthesis of oligosaccarides using a new type of insoluble support (a copolymer of polyethylene glycol and polystyrene) is described. Several Lewis acids were tested as activators of the trichloroacetimidate 12 , used as glycosyl donor, in the dimer 13 formation.
ADINOLFI M, BARONE G, DE NAPOLI L, IADONISI, ALFONSO, PICCIALLI G.   +4 more
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Solid-Phase Synthesis of Solanesol

Journal of Combinatorial Chemistry, 2008
An efficient and convergent solid-phase strategy for the total synthesis of All- E solanesol is described. This method features avoidance of iterative and difficult purifications comparing with solution-phase synthesis and is suitable for the preparation of other oligoprenols.
Xiongjie, Yu, Suxi, Wang, Fener, Chen
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Inclusion volume solid‐phase synthesis

Journal of Peptide Science, 1996
AbstractSolid‐phase synthesis of peptides was carried out using only the volume of the solvent included in the swollen solid‐phase resin beads [inclusion volume synthesis]. This approach enables (i) the use of higher concentrations of activated amino acids, resulting in increased coupling rates, (ii) drastically decreased consumption of solvents, and ...
J, Eichler, R A, Houghten, M, Lebl
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Solid phase synthesis of benzimidazolones

Tetrahedron Letters, 1996
Abstract An efficient solid phase synthesis of benzimidazoles is described. Polymer bound o-fluoronitroaromatic compound 2 was treated with an amine to give o-nitroaniline derivative 3 . Reduction of 3 with NaBH 4 Cu(acac) 2 followed by cyclization with an aryl imidate and cleavage with TFA gave 5 .
Gary B. Phillips, Guo Ping Wei
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Solid-Phase Synthesis

2000
The solid support strategy in solid-phase synthesis amino acids -alpha-amino protecting groups side-chain protecting groups solid supports for the synthesis of peptides and small molecules coupling methods - solid-phase formation of amide and ester bonds homodetic cyclic peptides disulfide formation in synthetic peptides and proteins -the state of the ...
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