Results 81 to 90 of about 422,636 (257)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Hall conductance of a non-Hermitian Weyl semimetal
New Journal of PhysicsIn recent years, non-Hermitian (NH) topological semimetals have garnered significant attention due to their unconventional properties. In this work, we explore one of the transport properties, namely the Hall conductance of a three-dimensional ...
Soumi Dey +3 more
doaj +1 more source
Aniline–phenol recognition: from solution through supramolecular synthons to cocrystals
IUCrJ, 2014 Aniline–phenol recognition is studied in the crystal engineering context in several 1:1 cocrystals that contain a closed cyclic hydrogen-bonded [...O—H...N—H...]2 tetramer supramolecular synthon (II). Twelve cocrystals of 3,4,5- and 2,3,4-trichlorophenol
Arijit Mukherjee +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
cis-[3-(2-Chloro-6-methylquinolin-3-yl)oxiran-2-yl](p-tolyl)methanone
IUCrData, 2017 In the title compound, C20H16ClNO2, the dihedral angle between the quinolyl ring system and the p-tolyl ring is 65.80 (7)°. The rings are bridged by a functionalized epoxide system, with the exocyclic bonds in a cis configuration.
Narasimhamurthy Preveena +4 more
doaj +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Spin density encodes intramolecular singlet exciton fission in pentacene dimers
Nature Communications, 2019 Singlet exciton fission – the separation of photoexcited singlet states into two triplet states – holds promise for enhancing photocurrents in photovoltaic technologies. Krishnapriya et al.
K. C. Krishnapriya +7 more
doaj +1 more source
On the Balance of Intercalation and Conversion Reactions in Battery Cathodes
, 2018 We present a thermodynamic analysis of the driving forces for intercalation and conversion reactions in battery cathodes across a range of possible working ion, transition metal, and anion chemistries.
Canepa, Pieremanuele +3 more
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Design Principles for High-Capacity Mn-Based Cation-Disordered Rocksalt Cathodes [PDF]
, 2020 Mn-based Li-excess cation-disordered rocksalt (DRX) oxyfluorides are promising candidates for next-generation rechargeable battery cathodes owing to their large energy densities, the earth abundance, and low cost of Mn.
Balasubramanian, M +13 more
core +1 more source