Adenylation Domain Engineering Enables Biosynthesis of an Improved Polymyxin Antibiotic
To enable incorporation of l‐2‐aminodecanoic acid into polymyxin by fermentation, a single Trp‐to‐Ala substitution is rationally introduced into the adenylation‐domain residue of its nonribosomal peptide synthetase (NRPS) and efficiently switches substrate selectivity. The engineered strain produces biologically active Ada‐polymyxin, demonstrating that
Maximilian Müll +7 more
wiley +2 more sources
Effects of Solid-State Fermentation by <i>Eurotium cristatum</i> on the Metabolic Profile of <i>Angelica dahurica</i>. [PDF]
Feng Y, Chen A, Chen K, Zeng L, Ran X.
europepmc +1 more source
Composite Microbial Solid-State Fermentation Enhances the Fermentation Quality, Nutritional Value, and Safety of Cottonseed Hulls: Insights Based on Physicochemical Detection and Untargeted Metabolomics. [PDF]
Yang H +6 more
europepmc +1 more source
Dynamics and Diversity of Microbial Community Succession During the Solid-State Fermentation Process of Fuzhuan Brick Sea Buckthorn Leaf Tea. [PDF]
Wang Y +8 more
europepmc +1 more source
Solid-state fermentation as a strategy for improvement of bioactive properties of the plant-based food resources. [PDF]
Yegin S.
europepmc +1 more source
Advancing solid-state fermentation with culinary fungi for nutrient-dense, minimally processed, whole-foods and resilient food systems-a narrative review. [PDF]
Gerber S +3 more
europepmc +1 more source
<i>Poria cocos</i> Solid-State Fermentation for Bioprocessing Tartary Buckwheat: Nutritional Enhancement, Antioxidant Activity, and Application in Steamed Bread. [PDF]
Fan W +6 more
europepmc +1 more source
Solid State Fermentation-A Promising Approach to Produce Meat Analogues. [PDF]
Milcarz A, Harasym J.
europepmc +1 more source
Flavonoid production via solid-state fermentation of agro-industrial waste with biopesticidal fungi: screening, optimization and scale-up. [PDF]
de Oliveira FR +4 more
europepmc +1 more source
Representation of the graphical abstract of the investigation of physicochemical, functional, and technological properties and amino acid profile of partially defatted flour and protein concentrate from Brazil nuts. ABSTRACT It was investigated the physicochemical, functional and technological properties and amino acid profile of partially defatted ...
Ana Vânia Carvalho +5 more
wiley +1 more source

