Results 91 to 100 of about 385,356 (336)

Crystal plasticity modeling of deformation behavior of Al–Al2Cu eutectics based on high-fidelity representative microstructures

Journal of Materials Research and Technology
A comprehensive understanding of material deformation behavior holds importance in enhancing the properties of materials, which can be achieved through modeling the relationship between microstructure and deformation behavior by an appropriate crystal ...
Meirong Jiang, Yiming Chen, Zhongsheng Yang, Xiaobing Hu, Lei Zhang, Junjie Li, Zhijun Wang, Shuangming Li, Jincheng Wang   +8 more
doaj   +1 more source

ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee, Keyue Chen, Ryan Loke, Xiang Li, David Liubart, Golam T. Saffi, Jonathan T. S. Chow, Ché M. P. Melo, Lydia To, Leonardo Salmena   +9 more
wiley   +1 more source

Multiple deformation mechanisms induce high work hardening in Ti–5Al–7.5 V alloy via transformed β matrix

Materials Research Letters
In this work, different transformed β matrix was obtained in Ti–5Al–7.5 V alloy. The alloy with equiaxed αp phase and transformed β matrix containing α′ martensite and β phase exhibits good combination of strength and plasticity, as well as a high work ...
Sisi Xie, Zhihong Wu, Nana Chen, Mingxiang Zhu, Hao Yang, Zilong Zhang, Chuanyun Wang, Jinshan Li, Hongchao Kou   +8 more
doaj   +1 more source

The critical role of DNA damage‐inducible transcript 4 (DDIT4) in stemness character of leukemia cells and leukemia initiation

Molecular Oncology, EarlyView.
Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li, Zhijie Cao, Haiyan Xing, Zhenya Xue, Wenbing Liu, Jiayuan Chen, Yihan Mei, Runxia Gu, Hui Wei, Shaowei Qiu, Min Wang, Qing Rao, Jianxiang Wang   +12 more
wiley   +1 more source

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

Research progress on formation and suppression of crack defects in oxide eutectic ceramics by laser additive manufacturing

Cailiao gongcheng
Oxide eutectic ceramics have excellent high specific strength, high temperature resistance, corrosion resistance, oxidation and creep resistance, and so on, which are considered to be the promising materials to be used in ultra-high temperature oxidation,
YAO Jiatong, SU Haijun, JIANG Hao, CHEN Qian, SHEN Zhonglin, YU Minghui, ZHANG Zhuo, GUO Min   +7 more
doaj   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

Modeling Inclusion Formation during Solidification of Steel: A Review

, 2017
The formation of nonmetallic inclusions in the solidification process can essentially influence the properties of steels. Computational simulation provides an effective and valuable method to study the process due to the difficulty of online ...
D. You, S. Michelic, P. Presoly, Jianhua Liu, C. Bernhard   +4 more
semanticscholar   +1 more source

Insight of the dendrite's deformation and fracture in large-sized single-crystal superalloy blades for the formation of slivers

Journal of Materials Research and Technology
The manufacturing of single-crystal superalloy blades consistently aims to avoid grain boundary defects that compromise crystal integrity. Although slivers represent a significant type of grain boundary defect, their formation mechanisms remain ...
Chao Zhang, Taiwen Huang, Hanyuan Xu, Yari Cai, Yuhan Zhou, Haitao Fu, Qian Huang, Jun Zhang, Lin Liu   +8 more
doaj   +1 more source

Eutectic colony formation: A phase field study

, 2001
Eutectic two-phase cells, also known as eutectic colonies, are commonly observed during the solidification of ternary alloys when the composition is close to a binary eutectic valley.
A. Karma, A. Karma, A. Karma, A. Karma, A.A. Wheeler, A.A. Wheeler, A.A. Wheeler, Alain Karma, B. Caroli, B. Nestler, C. Zener, D.G. McCartney, H.W. Weart, J. Tiaden, J.A. Warren, J.B. Bullock, J.B. Collins, J.D. Hunt, J.E. Gruzleski, J.E. Gruzleski, J.P. Chilton, J.S. Langer, J.W. Cahn, K. Brattkus, K.A. Jackson, K.R. Elder, M. Ginibre, M. Hillert, M. Plapp, M. Plapp, M. Plapp, M.D. Rinaldi, M.J. Aziz, Mathis Plapp, N. Provatas, N. Provatas, P. Kopczyński, P.K. Rohatgi, R.F. Almgren, R.W. Kraft, S. Akamatsu, S. Akamatsu, S. Akamatsu, T.S. Lo, V. Datye, W.H. Brandt, W.M. Rumball, W.W. Mullins, Y.-J. Chen   +48 more
core   +2 more sources