Results 91 to 100 of about 993,461 (297)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
DronesIn this study, we determined the distribution profile of different mineral fertilizers applied by a DJI Agras T50 remotely piloted aircraft (RPA) under different flight heights and speeds. The experiment was conducted in a randomized block design in a 3 ×
Luis Felipe Oliveira Ribeiro +7 more
doaj +1 more source
Strain-Rate Frequency Superposition in Large-Amplitude Oscillatory Shear
, 2010 In a recent work, Wyss, {\it et.al.} [Phys. Rev. Lett., {\bf 98}, 238303 (2007)] have noted a property of `soft solids' under oscillatory shear, the so-called strain-rate frequency superposition (SRFS).
A. Collyer +7 more
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Jamming of packings of frictionless particles with and without shear
, 2018 By minimizing the enthalpy of packings of frictionless particles, we obtain jammed solids at desired pressures and hence investigate the jamming transition with and without shear.
Xu, Ning, Zhang, Shiyun, Zheng, Wen
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Origin of Ising magnetism in Ca3Co2O6 unveiled by orbital imaging
Nature Communications, 2019 Ca$${}_{3}$$ 3 Co$${}_{2}$$ 2 O$${}_{6}$$ 6 has an unconventional magnetic structure displaying quantum tunnelling phenomena in its magnetization. Here, the authors use s-core-level non-resonant inelastic X-ray scattering to image the atomic Co 3d ...
Brett Leedahl +9 more
doaj +1 more source
Polaron Crossover in Molecular Solids
, 2004 An analytical variational method is applied to the molecular Holstein Hamiltonian in which the dispersive features of the dimension dependent phonon spectrum are taken into account by a force constant approach.
Das, A. N., Zoli, Marco
core +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source