Results 61 to 70 of about 154,023 (266)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Merging Phenotypic Stability Analysis and Genomic Prediction for Multi-Environment Breeding in Capsicum spp.

Agronomy
Capsicum spp. support diverse fresh and processing value chains, yet integrated assessments of phenotypic stability and genome-enabled prediction remain limited.
Sebastian Parra-Londono, Felipe López-Hernández, Guillermo Montoya, Juan Camilo Henao-Rojas, Gustavo A. Ossa-Ossa, Andrés J. Cortés   +5 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Cross-Sectional Distribution Profile of Mineral Fertilizers Applied by Remotely Piloted Aircraft Under Different Operating Parameters

Drones
In this study, we determined the distribution profile of different mineral fertilizers applied by a DJI Agras T50 remotely piloted aircraft (RPA) under different flight heights and speeds. The experiment was conducted in a randomized block design in a 3 ×
Luis Felipe Oliveira Ribeiro, Edney Leandro da Vitória, Jacimar Vieira Zanelato, João Victor Oliveira Ribeiro, Maria Eduarda da Silva Barbosa, Francisco de Assis Ferreira, Paulo Augusto Costa, Francine Bonomo Crispim Silva   +7 more
doaj   +1 more source

The Stability at the Solid-Solid and Liquid-Solid Interfaces

, 2016
In this thesis, we studied three small subjects in the realm of continuum mechanics: imbibition in fluid mechanics, beam and rod buckling in solid mechanics and shell buckling at the solid-liquid interface. In chapter 2, we examined the radial imbibition into a homogenous semi-infinite porous media from a point source with infinite liquid supply.
openaire   +2 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Multiple Dirac cones at the surface of the topological metal LaBi

Nature Communications, 2017
The magnetoresistance suggests an exotic topological phase in LaBi, but the evidence is still missing. Here, Nayaket al. report the existence of surface states of LaBi through the observation of three Dirac cones, confirming it a topological semimetal.
Jayita Nayak, Shu-Chun Wu, Nitesh Kumar, Chandra Shekhar, Sanjay Singh, Jörg Fink, Emile E. D. Rienks, Gerhard H. Fecher, Stuart S. P. Parkin, Binghai Yan, Claudia Felser   +10 more
doaj   +1 more source