Results 201 to 210 of about 951,609 (301)

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

FEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

Influence of Polymers Diversity on the Dissolution Kinetics of Encapsulated <i>p</i>-Coumaric Acid in Oral Systems. [PDF]

Gels
Jokubaite M, Jokubaityte-Tunkeviciene V, Ramanauskiene K.   +2 more
europepmc   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Silymarin and Silybin: Rejuvenating Traditional Remedies with Modern Delivery Strategies. [PDF]

Pharmaceutics
Li X, Zhu H, Wang Y, Zhang X, Yang Z, Yan X, Yu Q.   +6 more
europepmc   +1 more source

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

Ionic Liquids in Pharmaceuticals: A Scoping Review of Formulation Strategies. [PDF]

ACS Omega
Gonçalves Pereira IL, Ziulkoski AL, Zepon KM, Kanis LA, Schrekker HS.   +4 more
europepmc   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Different responses of fish/microbial transglutaminase to salt and ultrasound: Implications for myosin cross-linking. [PDF]

Ultrason Sonochem
Gao X, Gui M, Yu G, Zhao Y, Gao L, Liu R.   +5 more
europepmc   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Which halogen to choose? Comparing the effects of chlorine and fluorine as bioisosteric substituents in drug design. [PDF]

Chem Sci
Summerfield CJE, Pattison G.
europepmc   +1 more source