Results 221 to 230 of about 1,067,178 (339)

Solubility Enchantment Of Poorly Soluble Drug

open access: yes
The purpose of this evaluation was to enhance the solubility and bioavailability of poorly soluble medications through a variety of methods such as physical, chemical, and other modifications or techniques. Solubility refers to the maximum amount of solute that can dissolve in a specific amount of solvent or solution at a given temperature.
openaire   +1 more source

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald   +18 more
wiley   +1 more source

The Ionization Constant, Solubility Product, and Solubility of Abietic and Dehydroabietic Acid. [PDF]

open access: bronze, 1958
Vera Nyrén   +5 more
openalex   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

open access: yesMolecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach   +8 more
wiley   +1 more source

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