Results 171 to 180 of about 7,307 (207)
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International Journal of Biological Macromolecules, 2020
The inhibition of soluble epoxide hydrolase (sEH) is regarded as a promising therapeutic approach to treat inflammation and its related disorders. In present work, we investigated inhibitory effects of forty-nine kinds of traditional Chinese medicines against sEH.
Cheng-Peng Sun, Wen-Yu Zhao
exaly +3 more sources
The inhibition of soluble epoxide hydrolase (sEH) is regarded as a promising therapeutic approach to treat inflammation and its related disorders. In present work, we investigated inhibitory effects of forty-nine kinds of traditional Chinese medicines against sEH.
Cheng-Peng Sun, Wen-Yu Zhao
exaly +3 more sources
Phosphatase activity of soluble epoxide hydrolase
Prostaglandins and Other Lipid Mediators, 2017Soluble epoxide hydrolase (sEH) is a bifunctional enzyme that exhibits lipid epoxide hydrolase (sEH-H) and lipid phosphatase activity (sEH-P), with each being located in its own distinct domain. While the epoxide hydrolase activity is well-investigated, the role of the phosphatase domain remains unclear.
Ewgenij Proschak
exaly +3 more sources
Symmetric adamantyl-diureas as soluble epoxide hydrolase inhibitors [PDF]
Bioorganic and Medicinal Chemistry Letters, 2014 A series of inhibitors of the soluble epoxide hydrolase (sEH) containing two urea groups has been developed. Inhibition potency of the described compounds ranges from 2.0 μM to 0.4 nM.
Christophe Morisseau +2 more
exaly +3 more sources
Synthesis and structure–activity relationship of piperidine-derived non-urea soluble epoxide hydrolase inhibitors [PDF]
Bioorganic and Medicinal Chemistry Letters, 2013 A series of potent amide non-urea inhibitors of soluble epoxide hydrolase (sEH) is disclosed. The inhibition of soluble epoxide hydrolase leads to elevated levels of epoxyeicosatrienoic acids (EETs), and thus inhibitors of sEH represent one of a novel ...
Stevan Pecic +2 more
exaly +3 more sources
Polymorphisms in Human Soluble Epoxide Hydrolase
Molecular Pharmacology, 2003Human soluble epoxide hydrolase (hsEH) metabolizes a variety of epoxides to the corresponding vicinal diols. Arachidonic and linoleic acid epoxides are thought to be endogenous substrates for hsEH. Enzyme activity in humans shows high interindividual variation (e.g., 500-fold in liver) suggesting the existence of regulatory and/or structural gene ...
Beata D, Przybyla-Zawislak +9 more
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The role of soluble epoxide hydrolase in preeclampsia
Medical Hypotheses, 2017Preeclampsia is a serious complication of pregnancy characterized by the development of vasospasm, hypertension and often associated with proteinuria after the 20th week of gestation. Because termination of pregnancy results in the most efficacious resolution of preeclampsia, it is a leading cause of premature delivery worldwide.
Julia M. Santos +5 more
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Epoxylipids and soluble epoxide hydrolase in heart diseases
Biochemical Pharmacology, 2022Cardiovascular and heart diseases are leading causes of morbidity and mortality. Coronary artery endothelial and vascular dysfunction, inflammation, and mitochondrial dysfunction contribute to progression of heart diseases such as arrhythmias, congestive heart failure, and heart attacks.
John D, Imig +2 more
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Soluble epoxide hydrolase and ischemic cardiomyopathy
International Journal of Cardiology, 2012The development of cardiovascular disease has been linked to lowered levels of epoxyeicosatrienoic acids (EETs) in the cardiovascular system. Ischemic cardiomyopathy is caused by atherosclerotic lesions in multi-coronary arteries especially diffusive lesions, which can lead to severe myocardial dysfunction, heart enlargement, heart failure, or ...
Ting-Ting, Zhao +5 more
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Measurement of Soluble Epoxide Hydrolase (sEH) Activity
Current Protocols in Toxicology, 2007AbstractThe human soluble epoxide hydrolase (sEH; EC 3.3.3.2) is the product of the EXPH2 gene. The sEH catalyzes the addition of a water molecule to an epoxide, resulting in the corresponding diol. Early work suggested a role of sEH in detoxifying a wide array of xenobiotic epoxides; however, recent findings clearly implicate the sEH in the regulation
Christophe, Morisseau, Bruce D, Hammock
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Isolation and characterization of Xenopus soluble epoxide hydrolase
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2014Soluble epoxide hydrolase (sEH) contributes to cell growth, but the contribution of sEH to embryonic development is not well understood. In this study, Xenopus sEH cDNA was isolated from embryos of Xenopus laevis. The Xenopus sEH was expressed in Escherichia coli and was purified.
Endang R, Purba +2 more
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