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Soluble epoxide hydrolase and ischemic cardiomyopathy
International Journal of Cardiology, 2012The development of cardiovascular disease has been linked to lowered levels of epoxyeicosatrienoic acids (EETs) in the cardiovascular system. Ischemic cardiomyopathy is caused by atherosclerotic lesions in multi-coronary arteries especially diffusive lesions, which can lead to severe myocardial dysfunction, heart enlargement, heart failure, or ...
Ting-Ting, Zhao +5 more
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Epoxylipids and soluble epoxide hydrolase in heart diseases
Biochemical Pharmacology, 2022Cardiovascular and heart diseases are leading causes of morbidity and mortality. Coronary artery endothelial and vascular dysfunction, inflammation, and mitochondrial dysfunction contribute to progression of heart diseases such as arrhythmias, congestive heart failure, and heart attacks.
John D, Imig +2 more
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The role of soluble epoxide hydrolase in the intestine
Cell Biology InternationalAbstractThe soluble epoxide hydrolase (sEH; encoded by the EPHX2 gene) is an α/β hydrolase fold protein that is, widely distributed throughout the body. Recent studies have highlighted that sEH, in the metabolism of polyunsaturated fatty acids, plays a part in the pathogenesis of various diseases, including cardiovascular disease, Alzheimer's disease ...
Yanbei Ren, Ting Wang, Jiuheng Yin
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Measurement of Soluble Epoxide Hydrolase (sEH) Activity
Current Protocols in Toxicology, 2007Abstract The human soluble epoxide hydrolase (sEH; EC 3.3.3.2) is the product of the EXPH2 gene. The sEH catalyzes the addition of a water molecule to an epoxide, resulting in the corresponding diol.
Christophe, Morisseau, Bruce D, Hammock
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Isolation and characterization of Xenopus soluble epoxide hydrolase
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2014Soluble epoxide hydrolase (sEH) contributes to cell growth, but the contribution of sEH to embryonic development is not well understood. In this study, Xenopus sEH cDNA was isolated from embryos of Xenopus laevis. The Xenopus sEH was expressed in Escherichia coli and was purified.
Endang R, Purba +2 more
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Soluble Epoxide Hydrolase Inhibitors and Cardiovascular Diseases
Current Vascular Pharmacology, 2012Epoxyeicosatrienoic acids (EETs) have been shown to play a role in cardiovascular protection by reducing ischemia reperfusion injury, producing anti-inflammatory effects, and promoting angiogenesis. EETs are regulated through conversion to less active corresponding diols by soluble epoxide hydrolase (sEH).
Zhen-He, Wang +4 more
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The Soluble Epoxide Hydrolase as a Pharmaceutical Target for Hypertension
Journal of Cardiovascular Pharmacology, 2007The soluble epoxide hydrolase appears to be a promising target for the development of antihypertensive therapies based on a previously unexplored mechanism of action. Epoxide hydrolases are enzymes that add water to three membered cyclic ethers known as epoxides.
Nipavan, Chiamvimonvat +3 more
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Soluble epoxide hydrolase inhibitors: a patent review
Expert Opinion on Therapeutic Patents, 2010Soluble epoxide hydrolase (sEH) inhibitors have been shown to effectively increase the levels of epoxyeicosatrienoic acids and reduce the levels of dihydroxyeicosatrienoic acids, which may be translated to therapeutic potentials for multiple disease indications. It has been claimed that sEH inhibitors can be used to treat hypertension, diabetes, stroke,
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Diabetic CVD – Soluble Epoxide Hydrolase as A Target
Cardiovascular & Hematological Agents in Medicinal Chemistry, 2012The incidence of cardiovascular diseases remains high in diabetic patients despite the optimization of blood glucose control and the therapeutic management of risk factors. One emerging promising pharmacological approach that may help to prevent the development of diabetic cardiovascular complications is to improve endothelial function through the ...
Aurelien, Lorthioir +3 more
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Soluble Epoxide Hydrolase as a Stroke Target
2012Soluble epoxide hydrolase (sEH) is a promising therapeutic target for stroke. Both pharmacological inhibition and genetic knockout of sEH have shown protection in experimental models of cerebral ischemia. Additionally, human single-nucleotide polymorphisms in the gene that encodes for sEH, designated ephx2, have been correlated with stroke incidence ...
Jonathan W. Nelson, Nabil J. Alkayed
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