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The role of soluble epoxide hydrolase in the intestine
Cell Biology InternationalAbstractThe soluble epoxide hydrolase (sEH; encoded by the EPHX2 gene) is an α/β hydrolase fold protein that is, widely distributed throughout the body. Recent studies have highlighted that sEH, in the metabolism of polyunsaturated fatty acids, plays a part in the pathogenesis of various diseases, including cardiovascular disease, Alzheimer's disease ...
Yanbei Ren, Ting Wang, Jiuheng Yin
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Soluble Epoxide Hydrolase Inhibitors and Cardiovascular Diseases
Current Vascular Pharmacology, 2012Epoxyeicosatrienoic acids (EETs) have been shown to play a role in cardiovascular protection by reducing ischemia reperfusion injury, producing anti-inflammatory effects, and promoting angiogenesis. EETs are regulated through conversion to less active corresponding diols by soluble epoxide hydrolase (sEH).
Zhen-He, Wang +4 more
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The Soluble Epoxide Hydrolase as a Pharmaceutical Target for Hypertension
Journal of Cardiovascular Pharmacology, 2007The soluble epoxide hydrolase appears to be a promising target for the development of antihypertensive therapies based on a previously unexplored mechanism of action. Epoxide hydrolases are enzymes that add water to three membered cyclic ethers known as epoxides.
Nipavan, Chiamvimonvat +3 more
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Diabetic CVD – Soluble Epoxide Hydrolase as A Target
Cardiovascular & Hematological Agents in Medicinal Chemistry, 2012The incidence of cardiovascular diseases remains high in diabetic patients despite the optimization of blood glucose control and the therapeutic management of risk factors. One emerging promising pharmacological approach that may help to prevent the development of diabetic cardiovascular complications is to improve endothelial function through the ...
Aurelien, Lorthioir +3 more
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Discovery of enantioselectivity of urea inhibitors of soluble epoxide hydrolase
European Journal of Medicinal Chemistry, 2016Soluble epoxide hydrolase (sEH) hydrolyzes epoxyeicosatrienoic acids (EETs) in the metabolic pathway of arachidonic acid and has been considered as an important therapeutic target for chronic diseases such as hypertension, diabetes and inflammation. Although many urea derivatives are known as sEH inhibitors, the enantioselectivity of the inhibitors is ...
Manoj, Manickam +9 more
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Soluble epoxide hydrolase inhibitors: a patent review
Expert Opinion on Therapeutic Patents, 2010Soluble epoxide hydrolase (sEH) inhibitors have been shown to effectively increase the levels of epoxyeicosatrienoic acids and reduce the levels of dihydroxyeicosatrienoic acids, which may be translated to therapeutic potentials for multiple disease indications. It has been claimed that sEH inhibitors can be used to treat hypertension, diabetes, stroke,
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Soluble Epoxide Hydrolase as a Stroke Target
2012Soluble epoxide hydrolase (sEH) is a promising therapeutic target for stroke. Both pharmacological inhibition and genetic knockout of sEH have shown protection in experimental models of cerebral ischemia. Additionally, human single-nucleotide polymorphisms in the gene that encodes for sEH, designated ephx2, have been correlated with stroke incidence ...
Jonathan W. Nelson, Nabil J. Alkayed
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The Soluble Epoxide Hydrolase as a Pharmaceutical Target for Pain Management
Pain Management, 2011ISSN 1758-1869 10.2217/PMT.11.47 © 2011 Future Medicine Ltd Pain Manage. (2011) 1(5), 383–386 A newly characterized drug target, the soluble epoxide hydrolase (sEH), offers hope for developing new agents for the control of both inflammatory and neuropathic pain.
Bruce D, Hammock +2 more
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[Soluble epoxide hydrolase and lipid metabolism].
Sheng li ke xue jin zhan [Progress in physiology], 2012Soluble epoxide hydrolase (sEH) is widely distributed in mammalian tissues. Epoxyeicosatrienoic acids (EETs), as metabolites of arachidonic acid, are degraded by sEH. EETs may function as antihypertensive and antiarthrosclerotic mediators for vasculature. Therefore, sEH is closely related with cardiovascular diseases and inflammation.
Xin-Xin, Ma, Yan, Liu, Yi, Zhu
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Cardiovascular Therapeutic Aspects of Soluble Epoxide Hydrolase Inhibitors
Cardiovascular Drug Reviews, 2006ABSTRACTSoluble epoxide hydrolase (sEH) is an enzyme responsible for the conversion of lipid epoxides to diols by the addition of water. Biological actions on the cardiovascular system that are attributed to epoxides include vasodilation, antiinflammatory actions and vascular smooth muscle cell antimigratory actions.
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