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Coamorphous Solid Dispersion of a Soluble Epoxide Hydrolase Inhibitor t-TUCB with Amino Acid l-Arginine. [PDF]
Org Process Res DevHwang SH +7 more
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International Journal of Biological Macromolecules, 2020
The inhibition of soluble epoxide hydrolase (sEH) is regarded as a promising therapeutic approach to treat inflammation and its related disorders. In present work, we investigated inhibitory effects of forty-nine kinds of traditional Chinese medicines against sEH.
Chengpeng Sun, Wen-Yu Zhao, Xiaochi Ma
exaly +3 more sources
The inhibition of soluble epoxide hydrolase (sEH) is regarded as a promising therapeutic approach to treat inflammation and its related disorders. In present work, we investigated inhibitory effects of forty-nine kinds of traditional Chinese medicines against sEH.
Chengpeng Sun, Wen-Yu Zhao, Xiaochi Ma
exaly +3 more sources
International Journal of Biological Macromolecules, 2021
Inhibition of soluble epoxide hydrolase (sEH) is considered to be an effective treatment for inflammation-related diseases, and small molecules origin from natural products show promising activity against sEH. Two undescribed protostanes, 3β-hydroxy-25-anhydro-alisol F (1) and 3β-hydroxy-alisol G (2) were isolated from Alisma orientale and identified ...
Chengpeng Sun, Wen-Yu Zhao, Xiangge Tian
exaly +3 more sources
Inhibition of soluble epoxide hydrolase (sEH) is considered to be an effective treatment for inflammation-related diseases, and small molecules origin from natural products show promising activity against sEH. Two undescribed protostanes, 3β-hydroxy-25-anhydro-alisol F (1) and 3β-hydroxy-alisol G (2) were isolated from Alisma orientale and identified ...
Chengpeng Sun, Wen-Yu Zhao, Xiangge Tian
exaly +3 more sources
Phosphatase Activity of Soluble Epoxide Hydrolase
Prostaglandins and Other Lipid Mediators, 2017Soluble epoxide hydrolase (sEH) is a bifunctional enzyme that exhibits lipid epoxide hydrolase (sEH-H) and lipid phosphatase activity (sEH-P), with each being located in its own distinct domain. While the epoxide hydrolase activity is well-investigated, the role of the phosphatase domain remains unclear.
Ewgenij Proschak
exaly +3 more sources
Symmetric Adamantyl-Diureas as Soluble Epoxide Hydrolase Inhibitors [PDF]
Bioorganic and Medicinal Chemistry Letters, 2014 A series of inhibitors of the soluble epoxide hydrolase (sEH) containing two urea groups has been developed. Inhibition potency of the described compounds ranges from 2.0 μM to 0.4 nM.
Christophe Morisseau +2 more
exaly +2 more sources
Synthesis and Structure–Activity Relationship of Piperidine-Derived Non-Urea Soluble Epoxide Hydrolase Inhibitors [PDF]
Bioorganic and Medicinal Chemistry Letters, 2013 A series of potent amide non-urea inhibitors of soluble epoxide hydrolase (sEH) is disclosed. The inhibition of soluble epoxide hydrolase leads to elevated levels of epoxyeicosatrienoic acids (EETs), and thus inhibitors of sEH represent one of a novel ...
Alison Rinderspacher +2 more
exaly +2 more sources
Polymorphisms in Human Soluble Epoxide Hydrolase
Molecular Pharmacology, 2003Human soluble epoxide hydrolase (hsEH) metabolizes a variety of epoxides to the corresponding vicinal diols. Arachidonic and linoleic acid epoxides are thought to be endogenous substrates for hsEH. Enzyme activity in humans shows high interindividual variation (e.g., 500-fold in liver) suggesting the existence of regulatory and/or structural gene ...
Beata D, Przybyla-Zawislak +9 more
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The role of soluble epoxide hydrolase in preeclampsia
Medical Hypotheses, 2017Preeclampsia is a serious complication of pregnancy characterized by the development of vasospasm, hypertension and often associated with proteinuria after the 20th week of gestation. Because termination of pregnancy results in the most efficacious resolution of preeclampsia, it is a leading cause of premature delivery worldwide.
Julia M. Santos +5 more
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