Results 181 to 190 of about 15,414 (258)

Bioisosteric substitution of adamantane with bicyclic lipophilic groups improves water solubility of human soluble epoxide hydrolase inhibitors

, 2020
В. В. Бурмистров, Christophe Morisseau, Dmitry S. Karlov, Д. А. Питушкин, А. А. Вернигора, E. V. Rasskazova, Г. М. Бутов, Bruce D. Hammock   +7 more
openalex   +2 more sources

Epigenetic soluble epoxide hydrolase regulation causes endothelial dysfunction [PDF]

Acta Physiologica, 2018
openaire   +2 more sources

The soluble epoxide hydrolase inhibitor TPPU alleviates Aβ-mediated neuroinflammatory responses in Drosophila melanogaster and cellular models of alzheimer's disease. [PDF]

J Inflamm (Lond)
Sun X, Liu H, Li W, Li L, Tian Q, Cao Q, Meng Y, Shen Y, Che F, Chiu JC, Yu J, Hammock BD.   +11 more
europepmc   +1 more source

Metabolic and vascular contributions to dementia: Soluble epoxide hydrolase-derived linoleic acid oxylipins and glycemic status are related to cerebral small vessel disease markers, atrophy, and cognitive performance. [PDF]

Alzheimers Dement
Ryoo SW, Lin WZ, Magliocco A, Ruthirakuhan M, Wong YY, Perfetto SE, Huang C, Anita NZ, Arnott SR, Lang AE, Symons S, Hegele RA, Goubran M, Ramirez J, Ottoy J, Rabin JS, MacIntosh BJ, Lanctôt KL, Liang N, Cogo-Moreira H, Taha AY, Swardfager W, ONDRI Investigators.   +22 more
europepmc   +1 more source

Inhibition of soluble epoxide hydrolase confers neuroprotection and restores microglial homeostasis in a tauopathy mouse model. [PDF]

Mol Neurodegener
Wang S, Qi C, Rajpurohit C, Ghosh B, Xiong W, Wang B, Qi Y, Hwang SH, Hammock BD, Li H, Gan L, Zheng H.   +11 more
europepmc   +1 more source

Indole Alkaloids and Phenolic Amides from the Rhizomes of <i>Cimicifuga heracleifolia</i> and Their In Vitro Soluble Epoxide Hydrolase (sEH) Inhibitory Activity. [PDF]

Plants (Basel)
Sun Y, Fan C, Chen L, Cui X, Otsuki K, Zhang M, Qiu F, Ding L, Li W.   +8 more
europepmc   +1 more source

Soluble Epoxide Hydrolase Inhibition Improves Alzheimer's Disease Hallmarks: Correlation with Peripheral Inflammation and Gut Microbiota Modulation. [PDF]

Aging Dis
Jarne-Ferrer J, Griñán-Ferré C, Jora B, Codony S, Miró L, Rosell-Cardona C, Miñana-Galbis D, Pérez-Bosque A, Vazquez S, Pallàs M.   +9 more
europepmc   +1 more source

Inhibitors of soluble epoxide hydrolase and cGAS/STING repair defects in amyloid-β clearance underlying vascular complications of Alzheimer's disease. [PDF]

J Alzheimers Dis
Fiala M, Hammock BD, Hwang SH, Whitelegge J, Paul K, Kaczor-Urbanowicz KE, Urbanowicz A, Kesari S.   +7 more
europepmc   +1 more source

Allosteric Ensembles Elucidate Mechanisms of Inhibition in Human Soluble Epoxide Hydrolase

Conte M, Qiu Q, Carmona OG, Abis G, Fraternali F.   +4 more
europepmc   +1 more source

Microglial pro-inflammatory mechanisms induced by monomeric C-reactive protein are counteracted by soluble epoxide hydrolase inhibitors. [PDF]

Int Immunopharmacol
Bartra C, Vuraić K, Yuan Y, Codony S, Valdés-Quiroz H, Casal C, Slevin M, Máquez-Kisinousky L, Planas AM, Griñán-Ferré C, Pallàs M, Morisseau C, Hammock BD, Vázquez S, Suñol C, Sanfeliu C.   +15 more
europepmc   +1 more source