Results 91 to 100 of about 467,321 (167)

Evaluating Riociguat in the Treatment of Pulmonary Arterial Hypertension: A Real-World Perspective

Vascular Health and Risk Management, 2022
Andrew D Mihalek,1 Christopher D Scott,2 Sula Mazimba3 1Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Virginia, Charlottesville, VA, USA; 2Division of Thoracic Surgery, Department of Surgery, University of ...
Mihalek AD, Scott CD, Mazimba S
doaj  

BAY41-2272, a novel nitric oxide independent soluble guanylate cyclase activator, relaxes human and rabbit corpus cavernosum in vitro

, 2003
Purpose: In cavernous smooth muscle nitric oxide (NO) activates soluble guanylate cyclase, which catalyzes the synthesis of cyclic guanosine 3′,5′-monophosphate, leading to smooth muscle relaxation, increased blood flow and penile erection.
Rees, Rowland W., Royle, Michael, Moncada, Salvador, Kalsi, Jas S., Cellek, Selim, Hobbs, Adrian J., Kell, Phil D., Ralph, David J.   +7 more
core   +1 more source

The Role of Vericiguat in Early Phases of Anterior Myocardial Infarction: A Potential Game-Changer?

Medicina
Anterior myocardial infarction is a critical condition with significant implications for cardiac function and patient prognosis. Despite advancements in reperfusion therapies, optimizing recovery during the early phases of myocardial infarction remains ...
Federico Cacciapuoti, Ciro Mauro, Valentina Capone, Salvatore Chianese, Luca Gaetano Tarquinio, Rossella Gottilla, Fabio Marsico, Salvatore Crispo, Fulvio Cacciapuoti   +8 more
doaj   +1 more source

Soluble Guanylate Cyclase Generation of cGMP Regulates Migration of MGE Neurons

, 2015
Here we have provided evidence that nitric oxide-cyclic GMP (NO-cGMP) signaling regulates neurite length and migration of immature neurons derived from the medial ganglionic eminence (MGE).
Mandal, Shyamali, Buys, Emmanuel, Rubenstein, John L. R., Enikolopov, Grigori, Stanco, Amelia   +4 more
core   +1 more source

Yc-1 Potentiates the Antiplatelet Effect of Hydrogen Peroxide Via Sensitization of Soluble Guanylate Cyclase

, 2009
the present study, we showed that 3-(5'-hydroxymethyl-2'- furyl)-1-benzyl indazole (YC-1), a nitric oxide (NO)- independent activator of soluble guanylate cyclase, could potentiate H2O2-induced inhibition of platelet aggregation and increase of platelet ...
Wu, Chin-Chung; Kuo, Sheng-Chu; Lee, Fang-Yu; Teng, Che-Ming, 鄧哲明   +1 more
core  

Expression and function of soluble guanylate cyclase in pulmonary arterial hypertension

, 2008
Alterations of the nitric oxide receptor, soluble guanylate cyclase (sGC) may contribute to the pathophysiology of pulmonary arterial hypertension (PAH). In the present study, the expression of sGC in explanted lung tissue of PAH patients was studied and
Muller, D., Dingendorf, A., Schluter, K.D., Mittendorf, J., Middendorff, R., Ghofrani, H.A., Pullamsetti, S.S., Kolosionek, E., Grimminger, F., Klepetko, W., Stasch, J.P., Kaulen, C., Schermuly, R.T., Dumitrascu, R., Seeger, W., Weissmann, N., Hackemack, S.   +16 more
core  

Targeting the NO–sGC–cGMP Pathway: Mechanisms of Action of Vericiguat in Chronic Heart Failure

Cells
The recent advancements in the medical management of patients with chronic heart failure with reduced ejection fraction (HFrEF) is the soluble guanylate cyclase (sGC) stimulator, vericiguat.
Tine Bajec, Gregor Poglajen
doaj   +1 more source

Rationale and design of the SOluble guanylate Cyclase stimulatoR in heArT failurE Studies (SOCRATES)

, 2014
AimsThe clinical outcomes for patients with worsening chronic heart failure (WCHF) remain exceedingly poor despite contemporary evidence‐based therapies, and effective therapies are urgently needed.
Shah S, Atherton, John, Lam C, Kraigher-Krainer E, Müller K, Pieske B, Maggioni AP, Gheorghiade M, Solomon S, Roessig L, Filippatos G, Butler J, SOCRATES Investigators and Coordinators., Samano ET, Scalise AV, Ponikowski P   +15 more
core  

Tissue Guanosine-3',5'-Cyclic Monophosphate Levels and Soluble Guanylate Cyclase Activity A POSITIVE CORRELATION DURING UNILATERAL CRYPTORCHIDISM IN THE RAT TESTIS

, 2020
A B S T R A C T The relationship between the subcellular distribution of guanylate cyclase and tissue guanosine-3',5'-cyclic monophosphate (cGMP) levels was investigated in rat testes after surgically induced unilateral cryptorchidism ...
W Austin Spruill, Alton L Steiner, H Shelton Earp   +2 more
core  

Structures of soluble guanylate cyclase: implications for regulatory mechanisms and drug development.

, 2014
Activation of cGMP synthesis leads to vasodilation, and is an important mechanism in clinical treatment of angina, heart failure, and severe peripheral and pulmonary hypertension.
Gileadi, Opher, Gileadi, O, Opher Gileadi   +2 more
core   +1 more source