Results 81 to 90 of about 467,321 (167)

Lung‐Cardiovascular Interactions and Derangements in ARDS

Comprehensive Physiology, Volume 16, Issue 5, October 2026.
This review proposes an anatomical near‐ and far‐field framework for lung‐cardiovascular interactions in ARDS. Grounded in pathological and biological studies, the evidence spans pulmonary vascular, right ventricular, and systemic endothelial derangements and reviews available evidence for targeted therapies.
Pablo A. Sanchez, Connor O'Brien, Matthieu Legrand, Carolyn S. Calfee, Michael A. Matthay   +4 more
wiley   +1 more source

Soluble Guanylate Cyclase Generation of cGMP Regulates Migration of MGE Neurons [PDF]

, 2013
Here we have provided evidence that nitric oxide-cyclic GMP (NO-cGMP) signaling regulates neurite length and migration of immature neurons derived from the medial ganglionic eminence (MGE).
Mandal, Shyamali, Stanco, A., Enikolopov, Grigori, Buys, Emmanuel S, Buys, E. S., Stanco, Amelia, Enikolopov, G., Mandal, S., Rubenstein, J. L., Rubenstein, John LR   +9 more
core   +1 more source

NG-Nitro-L-arginine Methyl Ester, but Not Methylene Blue, Attenuates Anaphylactic Hypotension in Anesthetized Mice

Journal of Pharmacological Sciences, 2007
To clarify the role of NO in mouse anaphylactic hypotension, effects of a nitric oxide (NO) synthase inhibitor, NG-nitro-L-arginine methyl ester (L-NAME), on antigen-induced hypotension and portal hypertension were determined in anesthetized BALB/c mice.
Hiromichi Takano, Wei Liu, Zhansheng Zhao, Sen Cui, Wei Zhang, Toshishige Shibamoto   +5 more
doaj   +1 more source

Colorectal Cancer: Epidemiology, Risk Factors, Signaling Pathways, Clinical Features, Screening, Diagnosis, and Management

MedComm, Volume 7, Issue 10, October 2026.
Colorectal cancer is a heterogeneous, adaptive disease shaped by population‐level risk, genomic and epigenetic alterations, tumor ecosystem evolution, and treatment pressure. This review integrates epidemiology, risk factors, signaling networks, clinical presentation, screening, molecular diagnosis, and stage‐ and biomarker‐guided management while ...
Kairui Wan, Ke Tang, Linglong Wang, Qin Tian, Mingwei Zheng, Cheng Qian, Limei Liu   +6 more
wiley   +1 more source

Responsiveness of rat aorta and pulmonary artery to cGMP generators in the presence of thiol or heme oxidant

Journal of Pharmacological Sciences, 2019
This study investigated the effects of thiol and heme oxidants on responsiveness to cGMP generators in isolated rat aorta and pulmonary artery using an organ chamber.
Masashi Tawa, Yuka Yamashita, Takayoshi Masuoka, Katsuya Nakano, Junko Yoshida, Matomo Nishio, Takaharu Ishibashi   +6 more
doaj   +1 more source

Soluble guanylate cyclase and nitric oxide synthase in synaptosomal fractions of bovine retina

, 1998
Cyclic GMP has been shown in recent years to directly activate ion channels in bipolar and ganglion cells, and to indirectly regulate coupling between horizontal cells, and between bipolar and amacrine cells.
ALEXANDER MARGULIS, ARI SITARAMAYYA, LOAN DANG, NIKOLAY POZDNYAKOV   +3 more
core   +1 more source

cAMP regulates soluble guanylate cyclase beta 1-subunit gene expression in RFL-6 rat fetal lung fibroblasts

, 1993
Endothelium-derived relaxing factor (EDRF)/nitric oxide (NO) activates soluble guanylate cyclase, thereby stimulating the synthesis of guanosine 3',5'-cyclic monophosphate (cGMP).
S. P. Janssens, D. B. Bloch, A. Shimouchi, K. D. Bloch, W. M. Zapol   +4 more
core   +1 more source

Mechanism of tanshinones and phenolic acids from Danshen in the treatment of coronary heart disease based on co-expression network

BMC Complementary Medicine and Therapies, 2020
Background The tanshinones and phenolic acids in Salvia miltiorrhiza (also named Danshen) have been confirmed for the treatment of coronary heart disease (CHD), but the action mechanisms remain elusive.
Dongxue Wu, Mengqi Huo, Xi Chen, Yanling Zhang, Yanjiang Qiao   +4 more
doaj   +1 more source

A new small molecule inhibitor of soluble guanylate cyclase [PDF]

, 2015
Soluble guanylate cyclase (sGC) is a haem containing enzyme that regulates cardiovascular homeostasis and multiple mechanisms in the central and peripheral nervous system. Commonly used inhibitors of sGC activity act through oxidation of the haem moiety,
Garthwaite, John, Allerston, CK, Mota, Filipa, Hampden-Smith, Kathryn, Gane, P, Allerston, Charles K., Hampden-Smith, K, Selwood, David L., Mota, F, Garthwaite, J, Gane, Paul, Selwood, DL   +11 more
core   +1 more source

Management of Pulmonary Arterial Hypertension: Current Strategies and Future Prospects

Life
Primary pulmonary hypertension (PPH), now known as pulmonary arterial hypertension (PAH), has induced significant treatment breakthroughs in the past decade.
Munish Sharma, Vivek Paudyal, Saifullah Khalid Syed, Rubi Thapa, Nadeem Kassam, Salim Surani   +5 more
doaj   +1 more source