Results 171 to 180 of about 460,443 (348)
Artificial Receptor in Synthetic Cells Performs Transmembrane Activation of Proteolysis
Advanced Biology, Volume 9, Issue 5, May 2025.Transmembrane signaling is the hallmark of living cells and is among the highest challenges for the design of synthetic cells. Herein, an artificial receptor based on the chemistry of self‐immolative linkers is used to communicate information across the lipid bilayer, for transmembrane activation of enzymatic activity. Abstract The design of artificial,
Ane Bretschneider Søgaard +7 more
wiley +1 more source
Soluble stem cell factor receptor (CD117) and IL-2 receptor alpha chain (CD25) levels in the plasma of patients with mastocytosis: relationships to disease severity and bone marrow pathology [PDF]
, 2000 Cem Akin +6 more
openalex +3 more sources
Advanced Biology, Volume 9, Issue 4, April 2025.By systematizing a large body of evidence and propose a cascade relationship between protein homeostasis, endoplasmic reticulum stress, mitochondrial dysfunction, and pro‐fibrotic factor, providing a theoretical basis for ATII cells dysfunction as a possible pathophysiological initiating event for idiopathic pulmonary fibrosis.
Zhaoxiong Dong +6 more
wiley +1 more source
Mucus Physically Restricts Influenza A Viral Particle Access to the Epithelium
Advanced Biology, Volume 9, Issue 4, April 2025.The infectious potential of respiratory viruses depends on their ability to navigate through a layer of mucus that serves as a protective barrier in the lung. It is demonstrated that influenza A virus penetration through mucus is significantly limited by the gel's internal microstructure and, to a lesser extent, by adhesive binding to mucin glycans ...
Logan Kaler +8 more
wiley +1 more source
Cardiovascular Risk Biomarkers in Women with and Without Polycystic Ovary Syndrome
BiomoleculesObjective: Polycystic ovary syndrome (PCOS) is a prevalent metabolic disorder with an increased risk for cardiovascular disease (CVD) that is enhanced by obesity.
Manjula Nandakumar +4 more
doaj +1 more source
Spatiotemporal Control Over Protein Release from Artificial Cells via a Light‐Activatable Protease
Advanced Biology, Volume 9, Issue 5, May 2025.Stimulus‐responsive protein release is essential for intercellular communication. Mimicking this functionality in artificial cells is promising to study the working principles of cellular signaling. Herein, an engineered light‐activatable protease is implemented in a coacervate‐based artificial cell platform to establish user‐defined spatiotemporal ...
Arjan Hazegh Nikroo +4 more
wiley +1 more source
Journal of Lipid Research, 2005 Polyunsaturated fatty acids, including docosahexaenoic acid (DHA, 22:6n-3), modulate immune responses and exert beneficial immunosuppressive effects, but the molecular mechanisms inhibiting T-cell activation are not yet elucidated.
Qiurong Li +8 more
doaj
Light‐Triggered Protease‐Mediated Release of Actin‐Bound Cargo from Synthetic Cells
Advanced Biology, Volume 9, Issue 5, May 2025.TEV Prtoease‐mediated Releasable Actin‐binding Protein (TRAP) is a protein‐based platform consisting of a cargo tightly bound to reconstituted actin networks in synthetic cells which can be proteolyticly released from the bound actin, followed by its secretion through membrane translocation mediated by a cell‐penetrating peptide.
Mousumi Akter +3 more
wiley +1 more source
Targeting inflammatory pathways in axial spondyloarthritis. [PDF]
, 2019 The triggers and pathogenesis of axial spondyloarthritis (axSpA) are not yet completely understood. However, therapeutic agents targeting tumor necrosis factor-α and interleukin-17 inflammatory pathways have proven successful in suppressing many of the ...
Furst, Daniel E, Louie, James S
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