A Role for Soluble IL-6 Receptor in Osteoarthritis [PDF]
Journal of Functional Morphology and Kinesiology, 2017 Interleukin-6 (IL-6) is one of several pro-inflammatory cytokines present at elevated levels in the synovial fluid of individuals with confirmed clinical diagnosis of rheumatoid arthritis (RA) and osteoarthritis (OA).
Graham Akeson, Charles J. Malemud
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Polymorphisms in rs2069845 are associated with IL-6 and soluble IL-6 receptor levels during total joint replacement. [PDF]
PLoS ONEAs the number of patients undergoing total joint replacement (TJR) surgery increases, so does the number of revision surgeries. One driver of implant failure and subsequent revision surgery is peri-implant osteolysis, which is driven by inflammation ...
Kyle D Anderson +6 more
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IL-6 Trans-Signaling via the Soluble IL-6 Receptor: Importance for the Pro-Inflammatory Activities of IL-6 [PDF]
International Journal of Biological Sciences, 2012 Interleukin-6 (IL-6) is a cytokine with many activities. It has functions in the regulation of the immune system and the nervous system. Furthermore, IL-6 is involved in liver regeneration and in the metabolic control of the body.
Stefan Rose-John
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IL-6 triggers lysosomal degradation of LDL-R and enhances LDL-C uptake in vascular endothelial cells via macropinocytosis [PDF]
Molecular MedicineBackground Endothelial dysfunction profoundly compromises the barrier function that precludes trans-endothelial entry of low-density lipoprotein cholesterol (LDL-C) into the vessel wall.
Mulugeta M. Zegeye +7 more
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Glycan-based biological degraders targeting the cytokine immune axis [PDF]
Communications BiologyTargeted degradation of extracellular proteins via endo-lysosomal pathways constitutes a promising therapeutic strategy by enabling irreversible target removal and potentially reducing systemic effects of antigen accumulation. In this study, we present a
Michelle Seifert +10 more
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Identification of IL-6 Signalling Components as Predictors of Severity and Outcome in COVID-19
Frontiers in Immunology, 2022 IL-6 is one of the major mediators of the hyper-inflammatory responses with complex biological functions as it can signal via different modes of action.
María Ángeles Rodríguez-Hernández +18 more
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A Potential Role of IL-6/IL-6R in the Development and Management of Colon Cancer
Membranes, 2021 Colorectal cancer (CRC) is the third most frequent cancer worldwide and the second greatest cause of cancer deaths. About 75% of all CRCs are sporadic cancers and arise following somatic mutations, while about 10% are hereditary cancers caused by ...
Mimmo Turano +4 more
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Frontiers in Endocrinology, 2022 High level of interleukin 6 (IL-6), released by adipocytes in an obesity-induced, low grade inflammation state, is a regulator of insulin resistance and glucose tolerance.
Anna Rita Minafra +7 more
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Soluble interleukin-6 receptor in the COVID-19 cytokine storm syndrome
Cell Reports Medicine, 2021 Summary: Data suggest that interleukin (IL)-6 blockade could reduce mortality in severe COVID-19, yet IL-6 is only modestly elevated in most patients. Chen et al.
Luke Y.C. Chen +5 more
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Role of Interleukin-6 in Vascular Health and Disease
Frontiers in Molecular Biosciences, 2021 IL-6 is usually described as a pleiotropic cytokine produced in response to tissue injury or infection. As a pro-inflammatory cytokine, IL-6 activates innate and adaptative immune responses. IL-6 is released in the innate immune response by leukocytes as
Paulina Villar-Fincheira +7 more
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