Results 131 to 140 of about 9,609 (148)
Some of the next articles are maybe not open access.
Lung, 2019
Idiopathic pulmonary fibrosis (IPF) is a lethal disease with an unclear pathogenic mechanism. Components of the renin-angiotensin system (RAS) have a role in the pathogenesis of IPF, specifically, the aspartyl protease renin acts as a profibrotic factor in the lung. However, the concentration of the RAS components renin and soluble (pro)renin receptor (
Montes, Eduardo +4 more
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Idiopathic pulmonary fibrosis (IPF) is a lethal disease with an unclear pathogenic mechanism. Components of the renin-angiotensin system (RAS) have a role in the pathogenesis of IPF, specifically, the aspartyl protease renin acts as a profibrotic factor in the lung. However, the concentration of the RAS components renin and soluble (pro)renin receptor (
Montes, Eduardo +4 more
openaire +2 more sources
Sex differences in soluble (pro)renin receptor regulation of blood pressure
Physiology, 2023Background: Cleavage of the extra-cellular domain of the (pro)renin receptor (PRR) yields a soluble fragment (sPRR), that has been implicated in the pathogenesis of hypertension. We recently developed a novel mouse model with mutation in the cleavage site of the PRR using CRISPR/Cas9 such that sPRR is not generated.
Dhruvan Gopinath +4 more
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Current Opinion in Nephrology & Hypertension, 2022
Purpose of review The (pro)renin receptor (PRR), also termed as ATPase H+ transporting accessory protein 2 (ATP6AP2), was originally cloned as a specific receptor for prorenin and renin [together called (pro)renin]. Given the wide tissue distribution of PRR, PRR was further postulated to act as a regulator of tissue renin ...
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Purpose of review The (pro)renin receptor (PRR), also termed as ATPase H+ transporting accessory protein 2 (ATP6AP2), was originally cloned as a specific receptor for prorenin and renin [together called (pro)renin]. Given the wide tissue distribution of PRR, PRR was further postulated to act as a regulator of tissue renin ...
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Soluble (pro)renin receptor: a novel ligand for angiotensin II type 1 receptor?
Clinical Science, 2021Abstract This commentary highlights the study entitled ‘Soluble (pro)renin receptor induces endothelial dysfunction and hypertension in mice with diet-induced obesity via activation of angiotensin II type 1 receptor’ presented by Fu et al.
Keiichi Torimoto, Satoru Eguchi
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Hypertension, 2019
Objective: Preeclampsia (preE), a syndrome of hypertension, and end organ damage, is a leading cause of maternal and fetal morbidity and mortality. Recently, we and other researchers have shown that circulating (pro)renin, soluble (pro)renin receptor (s(P)RR) and placental (P)RR were significantly higher during preE compared to
Ahmed F Pantho +9 more
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Objective: Preeclampsia (preE), a syndrome of hypertension, and end organ damage, is a leading cause of maternal and fetal morbidity and mortality. Recently, we and other researchers have shown that circulating (pro)renin, soluble (pro)renin receptor (s(P)RR) and placental (P)RR were significantly higher during preE compared to
Ahmed F Pantho +9 more
openaire +1 more source
Hypertension
Background: Preeclampsia (preE) is a complex syndrome involving hypertension and proteinuria and although the definition and management continuously evolve as we learn more about this disease, it remains a leading cause of maternal and fetal morbidity and mortality.
Ashleigh Aubin +8 more
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Background: Preeclampsia (preE) is a complex syndrome involving hypertension and proteinuria and although the definition and management continuously evolve as we learn more about this disease, it remains a leading cause of maternal and fetal morbidity and mortality.
Ashleigh Aubin +8 more
openaire +1 more source
Hypertension, 2017
(Pro) renin receptor (PRR) is a new member of the renin-angiotensin system (RAS) and its role in chronic kidney disease largely remains elusive. We tested the role of PRR in albumin overload (OA) nephropathy. Uninephretomized Sprague-Dawley rats were treated for 7 weeks with vehicle, bovine serum albumin (BSA) (5 g/kg/d via a single i.p.
Hui Fang +10 more
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(Pro) renin receptor (PRR) is a new member of the renin-angiotensin system (RAS) and its role in chronic kidney disease largely remains elusive. We tested the role of PRR in albumin overload (OA) nephropathy. Uninephretomized Sprague-Dawley rats were treated for 7 weeks with vehicle, bovine serum albumin (BSA) (5 g/kg/d via a single i.p.
Hui Fang +10 more
openaire +1 more source
Role of the soluble (pro)renin receptor in diet induced obesity
PhysiologyBackground: Cleavage of the extra-cellular domain of the (pro)renin receptor (PRR) yields a soluble fragment (sPRR). Recent studies have reported elevated plasma sPRR levels in lipodystrophy as well as a therapeutic role for recombinant sPRR in diet induced obesity.
Deborah Stuart +2 more
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