Results 111 to 120 of about 9,553 (133)
Some of the next articles are maybe not open access.
Association of Soluble (Pro) Renin Receptor with Gestational Diabetes Mellitus
Endocrine Practice, 2015There is a need to identify biomarkers for gestational diabetes mellitus (GDM). Recently the soluble pro-renin receptor (s[Pro]RR) has been shown to be associated with GDM. We investigated the association of s(Pro) RR levels in Asian Indians with GDM.We recruited 222 pregnant females, 147 without GDM (non-GDM) and 75 with GDM visiting antenatal clinics
Kuppan, Gokulakrishnan +8 more
openaire +2 more sources
Soluble Form of the (Pro)Renin Receptor Generated by Intracellular Cleavage by Furin Is Secreted in Plasma [PDF]
Hypertension, 2009 The (pro)renin receptor [(P)RR] is a 35-kDa transmembrane protein that plays a pivotal role in angiotensin tissue generation and in nonproteolytic prorenin activation. We detected a soluble form of (P)RR [s(P)RR; 28 kDa] in the conditioned medium of cultured cells.
Laurent Müller +2 more
exaly +3 more sources
Serum level of soluble (pro)renin receptor is modulated in chronic kidney disease
Clinical and Experimental Nephrology, 2013Prorenin, the precursor of renin, binds to the (pro)renin receptor [(P)RR] and triggers intracellular signaling. The ligand binding sites of (P)RR are disconnected and are present in the soluble form of the receptor in serum. Given that the clinical significance of serum prorenin and soluble (P)RR in chronic kidney disease (CKD) is unclear, we ...
Atsuhiro Ichihara +2 more
exaly +3 more sources
Increased soluble (pro)renin receptor protein by autophagy inhibition in cultured cancer cells [PDF]
Genes To Cells, 2020 Abstract(Pro)renin receptor ((P)RR) regulates the renin–angiotensin system and functions as an essential accessory subunit of vacuolar H+‐ATPase. There is accumulating evidence that shows close relationship between (P)RR and autophagy. Soluble (P)RR consisting of the extracellular domain of (P)RR is generated from (P)RR by proteolytic enzymes.
exaly +3 more sources
Lung, 2019
Idiopathic pulmonary fibrosis (IPF) is a lethal disease with an unclear pathogenic mechanism. Components of the renin-angiotensin system (RAS) have a role in the pathogenesis of IPF, specifically, the aspartyl protease renin acts as a profibrotic factor in the lung. However, the concentration of the RAS components renin and soluble (pro)renin receptor (
Montes, Eduardo +4 more
openaire +2 more sources
Idiopathic pulmonary fibrosis (IPF) is a lethal disease with an unclear pathogenic mechanism. Components of the renin-angiotensin system (RAS) have a role in the pathogenesis of IPF, specifically, the aspartyl protease renin acts as a profibrotic factor in the lung. However, the concentration of the RAS components renin and soluble (pro)renin receptor (
Montes, Eduardo +4 more
openaire +2 more sources
Sex differences in soluble (pro)renin receptor regulation of blood pressure
Physiology, 2023Background: Cleavage of the extra-cellular domain of the (pro)renin receptor (PRR) yields a soluble fragment (sPRR), that has been implicated in the pathogenesis of hypertension. We recently developed a novel mouse model with mutation in the cleavage site of the PRR using CRISPR/Cas9 such that sPRR is not generated.
Dhruvan Gopinath +4 more
openaire +1 more source
Current Opinion in Nephrology & Hypertension, 2022
Purpose of review The (pro)renin receptor (PRR), also termed as ATPase H+ transporting accessory protein 2 (ATP6AP2), was originally cloned as a specific receptor for prorenin and renin [together called (pro)renin]. Given the wide tissue distribution of PRR, PRR was further postulated to act as a regulator of tissue renin ...
openaire +2 more sources
Purpose of review The (pro)renin receptor (PRR), also termed as ATPase H+ transporting accessory protein 2 (ATP6AP2), was originally cloned as a specific receptor for prorenin and renin [together called (pro)renin]. Given the wide tissue distribution of PRR, PRR was further postulated to act as a regulator of tissue renin ...
openaire +2 more sources
Soluble (pro)renin receptor: a novel ligand for angiotensin II type 1 receptor?
Clinical Science, 2021Abstract This commentary highlights the study entitled ‘Soluble (pro)renin receptor induces endothelial dysfunction and hypertension in mice with diet-induced obesity via activation of angiotensin II type 1 receptor’ presented by Fu et al.
Keiichi Torimoto, Satoru Eguchi
openaire +2 more sources
Hypertension, 2019
Objective: Preeclampsia (preE), a syndrome of hypertension, and end organ damage, is a leading cause of maternal and fetal morbidity and mortality. Recently, we and other researchers have shown that circulating (pro)renin, soluble (pro)renin receptor (s(P)RR) and placental (P)RR were significantly higher during preE compared to
Ahmed F Pantho +9 more
openaire +1 more source
Objective: Preeclampsia (preE), a syndrome of hypertension, and end organ damage, is a leading cause of maternal and fetal morbidity and mortality. Recently, we and other researchers have shown that circulating (pro)renin, soluble (pro)renin receptor (s(P)RR) and placental (P)RR were significantly higher during preE compared to
Ahmed F Pantho +9 more
openaire +1 more source
Elevated Plasma Soluble (Pro)renin receptor as a potential indicator for heart failure
PeptidesIncreasing evidence has demonstrated that sPRR [a truncated soluble form of (pro)renin receptor] levels may reflect the severity of several diseases, including kidney disease, hypertension, and heart failure (HF). Although previous studies using cohorts primarily consisting of HF patients with reduced ejection fraction revealed that increased plasma ...
Chuanming Xu, Huiru Yang, Xiaoli Yi
exaly +3 more sources