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The (pro)renin receptor ((P)RR) and soluble (pro)renin receptor (s(P)RR) in pregnancy
Placenta, 2021The (pro)renin receptor ((P)RR) is a multi-functional protein that can be proteolytically cleaved and released in a soluble form (s(P)RR). Recently, the (P)RR and s(P)RR have become of interest in pregnancy and its associated pathologies. This is because the (P)RR not only activates tissue renin angiotensin systems, but it is also an integral component
Saije Endacott +2 more
exaly +3 more sources
Cleavage of the soluble (pro)renin receptor (sATP6AP2) in the placenta
Placenta, 2020The (pro)renin receptor (ATP6AP2) is cleaved and released as soluble ATP6AP2 (sATP6AP2). The sATP6AP2 is detected in plasma and urine and is elevated in women with gestational diabetes and preeclampsia. The source and cleavage pathway of sATP6AP2 in pregnancy is unknown.
Saije Endacott +2 more
exaly +3 more sources
The (pro)renin receptor and soluble (pro)renin receptor in choriocarcinoma
Reproduction, 2021Abstract This study aimed to determine if the (pro)renin receptor (ATP6AP2) changes the cellular profile of choriocarcinomas from cytotrophoblast cells to terminally syncytialised cells and ascertain whether this impacts the invasive potential of choriocarcinoma cells.
Morosin, Saije K. +5 more
openaire +2 more sources
Placenta, 2016
The prorenin receptor ((P)RR) contributes to the regulation of the tissue renin-angiotensin system (RAS) and the function of V-ATPase, which are essential for Wnt signaling. Thus, (P)RRs may be involved in the control both of feto-placental and maternal circulation during pregnancy. This study was conducted to clarify how placental (P)RR expression and
Hiroyuki Seki +2 more
exaly +3 more sources
The prorenin receptor ((P)RR) contributes to the regulation of the tissue renin-angiotensin system (RAS) and the function of V-ATPase, which are essential for Wnt signaling. Thus, (P)RRs may be involved in the control both of feto-placental and maternal circulation during pregnancy. This study was conducted to clarify how placental (P)RR expression and
Hiroyuki Seki +2 more
exaly +3 more sources
Soluble (Pro) Renin Receptor is a Predictor of Gestational Diabetes Mellitus
Current Diabetes Reviews, 2017Gestational diabetes mellitus (GDM) is a common endocrine complication in pregnancy. While it has been established that age, family history of diabetes, insulin resistance and several biomarkers are associated with GDM but significant gaps remain in understanding risk factors for GDM.
Shokoufeh Bonakdaran, Fatemeh Tara
exaly +3 more sources
Novel sandwich ELISA for detecting the human soluble pro renin receptor
Frontiers in Bioscience - Elite, 2013 The (pro)renin receptor ((P)RR) plays a key role in the activation of the local renin-angiotensin system via interaction with renin and prorenin. A truncated form that is cleaved by furin, referred to as soluble (pro)renin receptor (s(P)RR), is secreted into the extracellular space. An accurate measurement of s(P)RR levels in vivo is an important issue
Atsuhiro Ichihara
exaly +3 more sources
Soluble (pro)renin receptor in preeclampsia and diabetic pregnancies
Journal of the American Society of Hypertension, 2017Women with preexisting or gestational diabetes mellitus have an increased risk for developing preeclampsia. Diabetes and pregnancy are both characterized by very high prorenin levels and renin-angiotensin system activation. Prorenin bound to the (pro)renin receptor has enzymatic activity.
Meryam Sugulle +7 more
openaire +3 more sources
The Soluble (Pro)Renin Receptor in Health and Diseases: Foe or Friend?
The Journal of Pharmacology and Experimental Therapeutics, 2021The (pro)renin receptor (PRR) is a single-transmembrane protein that regulates the local renin-angiotensin system and participates in various intracellular signaling pathways, thus exhibiting a significant physiopathologic relevance in cellular homeostasis.
Manman, Qin, Chuanming, Xu, Jun, Yu
openaire +2 more sources