Results 41 to 50 of about 402 (126)

Cardiotoxicity of BRAF/MEK inhibitors

British Journal of Pharmacology, EarlyView.
Abstract Rapidly accelerated fibrosarcoma type B/B‐Raf proto‐oncogene, serine/threonine kinase (BRAF) and mitogen‐activated protein kinase (MEK) inhibitors have transformed outcomes in cancer therapy, particularly in melanoma. However, cardiovascular toxicities are increasingly recognized in real‐world clinical practice.
Katharina Seuthe, Valerie Lohner, Kevin Terre, Thomas Riffelmacher, Roman Pfister   +4 more
wiley   +1 more source

Immunomodulatory mediators IL-33, soluble ST2, IL-10, IFN-γ in the serum of patients with oral potentially malignant disorders and oral squamous cell carcinoma

Frontiers in Oral Health
BackgroundInterleukin-33 (IL-33) and its receptor Suppression of tumorigenicity 2 (ST2), along with IL-10 and IFN-γ, exert contrasting roles in tumor growth, immune evasion, and host defense.
Swetha Acharya, Usha Hegde, Subba Rao Venkata Madhunapantula, Medha Karnik, Anirudh Balakrishna Acharya, Pushparaja Shetty   +5 more
doaj   +1 more source

Interleukin-33 Receptor (ST2) Deficiency Improves the Outcome of Staphylococcus aureus-Induced Septic Arthritis

Frontiers in Immunology, 2018
The ST2 receptor is a member of the Toll/IL-1R superfamily and interleukin-33 (IL-33) is its agonist. Recently, it has been demonstrated that IL-33/ST2 axis plays key roles in inflammation and immune mediated diseases. Here, we investigated the effect of
Larissa Staurengo-Ferrari, Silvia C. Trevelin, Silvia C. Trevelin, Victor Fattori, Daniele C. Nascimento, Kalil A. de Lima, Jacinta S. Pelayo, Florêncio Figueiredo, Rubia Casagrande, Sandra Y. Fukada, Mauro M. Teixeira, Thiago M. Cunha, Foo Y. Liew, Rene D. Oliveira, Paulo Louzada-Junior, Fernando Q. Cunha, José C. Alves-Filho, Waldiceu A. Verri   +17 more
doaj   +1 more source

Serum CD40L, ST2, IL-6, and CRP serving as biomarkers for acute coronary syndrome

European Journal of Inflammation, 2022
To analyze the diagnostic value of CD40 ligand (CD40L), soluble growth stimulating expression gene 2 protein (ST2), interleukin-6 (IL-6), and C-reactive protein (CRP) are used in patients with acute coronary syndrome (ACS).
Li Zhu, Chuanmeng Zhang, Guangyao Mao, Jie Xu, Jingyu Qian, Lin Jiang, Jun Ye   +6 more
doaj   +1 more source

From scarring to healing: Emerging regenerative therapies for pulmonary fibrosis using MSCs and exosomes

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
MSCs exert anti‐inflammatory, anti‐fibrotic and regenerative effects in pulmonary fibrosis. MSC‐derived exosomes reproduce many therapeutic benefits of parental MSCs. Preconditioning and genetic modification improve MSC therapeutic performance. Current preclinical and clinical evidence supports the translational potential of MSC‐based therapies ...
Hajar Nasiri, Farbod Khosravi, Fatemeh Eskandari, Tahereh Manoochehrabadi, Ali Samadikuchaksaraei, Ehsan Lotfi, Jila Majidi, Fatemeh Rafati, Zeynab Ghorbani   +8 more
wiley   +1 more source

Prognostic value of soluble ST2 in adults with congenital heart disease [PDF]

Heart, 2019
Objective Soluble suppression of tumourigenicity-2 (sST2) is upregulated as response to myocardial stress and may be a potential biomarker for risk stratification in patients with adult congenital heart disease (ACHD). This study aimed to investigate the release of sST2 and its association with cardiovascular events
Laurie W Geenen, Vivan J M Baggen, Annemien E van den Bosch, Jannet A Eindhoven, Judith A A E Cuypers, Maarten Witsenburg, Eric Boersma, Jolien W Roos-Hesselink   +7 more
openaire   +2 more sources

The prognostic value of circulating soluble ST2 in patients with chronic heart failure

Journal of International Medical Research
Objective The purpose of this study was to assess whether circulating soluble ST2 independently predicts prognosis in patients with chronic heart failure. Methods This study was registered with the International Prospective Register of Systematic Reviews
Yue Zhang, Yunhong Liu, Yuanxia Yang, Lei Peng, Pengyu Zhong, Xiaoxin Jiang   +5 more
doaj   +1 more source

The ST2/IL-33 Axis in Immune Cells during Inflammatory Diseases

Frontiers in Immunology, 2017
Il1rl1 (also known as ST2) is a member of the IL-1 superfamily, and its only known ligand is IL-33. ST2 exists in two forms as splice variants: a soluble form (sST2), which acts as a decoy receptor, sequesters free IL-33, and does not signal, and a ...
Sophie Paczesny, Sophie Paczesny, Sophie Paczesny, Brad Griesenauer, Brad Griesenauer, Brad Griesenauer   +5 more
doaj   +1 more source

Sequence of Immunological Events During IgE‐Mediated Allergic Reactions to Food

Allergy, Volume 81, Issue 8, Page 2726-2743, August 2026.
ABSTRACT Food allergies (FA) represent a significant global health burden. Upon allergen re‐exposure, allergic patients exhibit a sequence of symptoms that vary in terms of affected organ systems, severity, time of onset and allergen reactivity thresholds.
N. A. Nagy, D. Schnoegl, V. Houghton, L. O'Mahony, A. F. Santos, E. F. Knol, A. Kuehn, T. Eiwegger   +7 more
wiley   +1 more source

Targeting Immunologic Pathways in Eosinophilic Granulomatosis With Polyangiitis: Translating Emerging Evidence Into Clinical Practice

Allergy, Volume 81, Issue 8, Page 2775-2791, August 2026.
ABSTRACT Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare and potentially life‐threatening systemic, inflammatory disease with multi‐organ manifestations, variable presentation and complex pathology. Multiple interconnected immunological pathways are implicated in EGPA pathology, including a type‐2 immune response driving predominantly ...
Harold Wilson‐Morkeh, Lior Seluk, Philipp Bosch, Carolina Aguiar, Jens Thiel, Bernhard Hellmich, Michael E. Wechsler, Salman Siddiqui   +7 more
wiley   +1 more source