Results 51 to 60 of about 13,720 (213)

Exercise-induced Changes in Soluble ST2 Concentrations in Marathon Runners [PDF]

Medicine & Science in Sports & Exercise, 2019
ABSTRACT Purpose Previous studies have suggested that extreme endurance exercise may induce cardiac microdamage that could lead to subsequent myocardial fibrosis. Soluble suppression of tumorigenicity 2 (sST2) is a cardiac biomarker for assessment of myocardial fibrosis, inflammation, and strain. We evaluated baseline
Aengevaeren, V.L., Kimmenade, R.R.J. van, Hopman, M.T.E., Royen, N. van, Snider, James V., Januzzi, J.L., Jr., George, K.P., Eijsvogels, T.M.H.   +7 more
openaire   +4 more sources

An interleukin-33/ST2 signaling deficiency reduces overt pain-like behaviors in mice [PDF]

, 2013
Interleukin (IL)-33, the most recent member of the IL family of cytokines, signals through the ST2 receptor. IL-33/ST2 signaling mediates antigen challenge-induced mechanical hyperalgesia in the joints and cutaneous tissues of immunized mice. The present
Alves-Filho, J.C., Casagrande, R., Cunha, F.Q., Cunha, T.M., Ferreira, S.H., Hohmann, M.S.N., Liew, F.Y., Magro, D.A.C., Mizokami, S.S., Verri Jr, W.A.   +9 more
core   +3 more sources

Role of IL-33 and ST2 signalling pathway in multiple sclerosis: expression by oligodendrocytes and inhibition of myelination in central nervous system [PDF]

, 2016
Recent research findings have provided convincing evidence indicating a role for Interleukin-33 (IL-33) signalling pathway in a number of central nervous system (CNS) diseases including multiple sclerosis (MS) and Alzheimer’s disease.
Allan, Debbie, Barnett, Susan C., Elliott, Christina, Fairlie-Clarke, Karen J., Jiang, Hui-Rong, Lassmann, Hans, Linnington, Christopher, Schuh, Cornelia   +7 more
core   +2 more sources

A combined clinical and biomarker approach to predict diuretic response in acute heart failure [PDF]

, 2015
Background: Poor diuretic response in acute heart failure is related to poor clinical outcome. The underlying mechanisms and pathophysiology behind diuretic resistance are incompletely understood.
Bloomfield, Daniel M., Bruno, Noemi, Cleland, John G.F., Cotter, Gad, Damman, Kevin, Davison, Beth, Dittrich, Howard C., Givertz, Michael M., Hillege, Hans L., Metra, Marco, O’Connor, Christopher M., Ponikowski, Piotr, Teerlink, John R., ter Maaten, Jozine M., Valente, Mattia A.E., van Veldhuisen, Dirk J., Voors, Adriaan A.   +16 more
core   +4 more sources

Common Genetic Variation at the IL1RL1 Locus Regulates IL-33/ST2 Signaling [PDF]

, 2013
The suppression of tumorigenicity 2/IL-33 (ST2/IL-33) pathway has been implicated in several immune and inflammatory diseases. ST2 is produced as 2 isoforms.
Abbas Dehghan, Anahita Ghorbani, Andrew D. Johnson, Chen Lu, Christopher J. O’Donnell, Christopher Newton-Cheh, Daniel Levy, Elizabeth L. McCabe, Eric R. Schreiter, Erin Coglianese, Honghuang Lin, James L. Januzzi, Janine F. Felix, Jennifer E. Ho, Kannel, Kurowska-Stolarska, Martin G. Larson, Ming-Huei Chen, Nora Franceschini, Ramachandran S. Vasan, Richard T. Lee, Stefan Walter, Susan Cheng, Thomas J. Wang, Turnquist, Valur Emilsson, Walter, Wei-Yu Chen   +27 more
core   +7 more sources

Soluble ST2 suppresses IL-5 production by human basophilic KU812 cells, induced by epithelial cell-derived IL-33

Allergology International, 2018
Background: Epithelial cell-derived IL-33 has an important role in the initiation and activation of innate allergic inflammation. IL-33 acts as a cytokine through the ST2 receptor (ST2L) and it stimulates the production of Th2 cytokines.
Koji Matsumoto, Hideaki Kouzaki, Hirotaka Kikuoka, Tomohisa Kato, Ichiro Tojima, Shino Shimizu, Takeshi Shimizu   +6 more
doaj   +1 more source

ST2 levels increased and were associated with changes in left ventricular systolic function during a three-year follow-up after adjuvant radiotherapy for breast cancer

Breast, 2020
Objectives: To search for biomarkers of RT-induced cardiotoxicity, we studied the behavior of ST2 during RT and three years after RT, and the associations with echocardiographic changes.
Hanna Aula, Tanja Skyttä, Suvi Tuohinen, Tiina Luukkaala, Mari Hämäläinen, Vesa Virtanen, Pekka Raatikainen, Eeva Moilanen, Pirkko-Liisa Kellokumpu-Lehtinen   +8 more
doaj   +1 more source

Soluble ST2 predicts outcome and hemorrhagic transformation after acute stroke [PDF]

Annals of Clinical and Translational Neurology, 2017
ST2 is a member of the toll-like receptor superfamily that can alter inflammatory signaling of helper T-cells. We investigated whether soluble ST2 (sST2) could independently predict outcome and hemorrhagic transformation (HT) in the setting of stroke.We measured sST2 in patients enrolled in the Specialized Program of Translational Research in Acute ...
Wolcott, Zoe, Batra, Ayush, Bevers, Matthew B., Sastre, Cristina, Khoury, Jane, Sperling, Matthew, Meyer, Brett C., Walsh, Kyle B., Adeoye, Opeolu, Broderick, Joseph P., Kimberly, W. Taylor   +10 more
openaire   +2 more sources

IL-33 ameliorates Alzheimer’s disease-like pathology and cognitive decline [PDF]

, 2016
Alzheimer’s disease (AD) is a devastating condition with no known effective treatment. AD is characterized by memory loss as well as impaired locomotor ability, reasoning, and judgment.
Chan, Ivy C. W., Cheung, Tom H., Fu, Amy K. Y., Fu, Wing-Yu, Hung, Kwok-Wang, Ip, Nancy Y., Liew, Foo Y., Mak, Deejay S. Y., Yuen, Michael Y. F., Zhang, Baorong, Zhou, Xiaopu   +10 more
core   +1 more source

Serum soluble ST2 is associated with ER-positive breast cancer [PDF]

BMC Cancer, 2014
Abstract Background ST2, a member of the interleukin (IL)-1receptor family, regulates Th1/Th2 immune responses in autoimmune and inflammatory conditions. However, the role of ST2 signaling in tumor growth and metastasis of breast cancers has not been investigated.
Lu, Da-peng, Zhou, Xiang-yu, Yao, Lu-tian, Liu, Cai-gang, Ma, Wei, Jin, Feng, Wu, Yun-fei   +6 more
openaire   +2 more sources