Results 41 to 50 of about 1,044,480 (214)

Assessment of Some Iron Metabolism Biomarkers in Patients with Ischemic Heart Disease

Medical Journal of Babylon
Background: Ischemic heart disease (IHD) is the most common form of cardiovascular disease. Objectives: This study aimed to assess changes in iron metabolism and red blood cell (RBC) biomarkers in patients with IHD.
Hanna Abdulkareem Hussein, Maysaa Adil Hadi, Walaa Salih Hassan   +2 more
doaj   +1 more source

Fibrillation of transferrin [PDF]

, 2012
The nature of fibrillar deposits from aqueous solutions of human serum and recombinant human transferrin on mica and carbon-coated formvar surfaces has been ...
Moreton, Ben, Costantini, Giovanni, Scrivens, James H., Sadler, P. J., Scarff, Charlotte A., Giovanni Costantini, Scrivens, James, Charlotte A. Scarff, Peter J. Sadler, Sadler, Peter J., Booyjzsen, Claire, Ben Moreton, Portman, Ian, James H. Scrivens, Claire Booyjz̈sen, Portman, Ian J., Ian Portman   +16 more
core   +1 more source

TROP2‐Targeting Chimeras (TRTACs) for Tumor Cell‐Selective Membrane Protein Degradation and Enhanced Drug Delivery

Advanced Science, EarlyView.
TROP2 is identified as a novel tumor‐selective lysosomal‐targeting receptor with established clinical relevance. TROP2‐targeting chimeras (TRTACs) are developed by genetically fusing a TROP2‐binding nanobody to nanobodies against specific target proteins.
Luping Chen, Xinying Fu, Wenqian Dong, Xiaobei Deng, Simin Chen, Fujun Wang, Jian Zhao, Shiqun Shao, Liqiang Fan, Jingyu Zhang, Lixin Zhang   +10 more
wiley   +1 more source

Biology and receptor interactions of P97 and the transferrin receptors

, 2002
Melanotransferrin, or p97, is an iron binding protein that is expressed as both a glycosylphosphatidylinositol-anchored form and as a soluble form. While the anchored form internalizes iron, the function of the soluble form is still unknown.
Walker, Brandie Laurel
core   +1 more source

DNA-binding transferrin conjugates as functional gene-delivery agents: synthesis by linkage of polylysine or ethidium homodimer to the transferrin carbohydrate moiety [PDF]

, 1991
We have previously demonstrated that transferrin-polycation conjugates are efficient carrier molecules for the introduction of genes into eucariotic cells.
Mechtler, Karl, Kirlappos, Helen, Wagner, Ernst, Birnstiel, Max L., Cotten, Matt   +4 more
core   +1 more source

Engineered Peptide Self‐Assembled Nanofibers for Enhanced STING Activation: A Promising Nanodelivery Platform for Immunotherapy of Pediatric Solid Tumors

Advanced Science, EarlyView.
An engineered peptide self‐assembled nanofiber platform, designed to replicate STING–cGAMP binding motifs, facilitates pH‐responsive cytosolic delivery of cGAMP, enhances the endoplasmic reticulum with high efficiency, and robustly activates the STING pathway.
Yubin He, Xiao Lu, Chang qing Yang, Ran Zhang, Bo Wan, Xin Ni, Dong Mei   +6 more
wiley   +1 more source

Magnetoreceptor Promotes Hepatocellular Carcinoma Development and Blunts Sorafenib‐Induced Ferroptosis by Regulating Iron Homeostasis

Advanced Science, EarlyView.
Magnetoreceptor (MagR) regulates iron homeostasis and mitochondrial function in hepatocellular carcinoma (HCC) cells. Specifically, MagR deficiency suppresses tumor cell proliferation, migration, and invasion and enhances sorafenib‐induced ferroptosis through iron accumulation.
Tao Wang, Chenghua Song, Xin He, Mengzhou Wang, Wuming Liu, Xiaolin Wang, Yuanyuan Zhang, Jia Zhang, Lin Zhang, Dan Li, Yu Zhang, Zheng Wu, Yi Lyu, Rongqian Wu   +13 more
wiley   +1 more source

Niosomes and polymeric chitosan based vesicles bearing transferrin and glucose ligands for drug targeting [PDF]

, 2000
PURPOSE: To prepare polymeric vesicles and niosomes bearing glucose or transferrin ligands for drug targeting. METHODS: A glucose-palmitoyl glycol chitosan (PGC) conjugate was synthesised and glucose-PGC polymeric vesicles prepared by sonication of ...
Dufès, Christine, Uchegbu, I.F., Couet, W., Tetley, L., Gray, A.I., Watson, D.G., Olivier, J.C., Schätzlein, A.G.   +7 more
core   +3 more sources

Assessing iron metabolism parameters in pregnant women with different preeclampsia phenotypes

Акушерство, гинекология и репродукция
Aim: to determine iron metabolism parameters in the blood of pregnant women with different preeclampsia (РЕ) phenotypes.Materials and Methods. A single-center prospective comparative case-control study was conducted that assessed clinical, anamnestic ...
I. Ya. Usman, I. V. Ignatko, I. A. Fedyunina, E. V. Timokhina, A. A. Churganova, S. F. Askerova   +5 more
doaj   +1 more source

Oxidant status, iron homeostasis, and carotenoid levels of COPD patients with advanced disease and LTOT

European Clinical Respiratory Journal, 2018
Background: The pathogenesis of chronic obstructive pulmonary disease (COPD) is associated with oxidative stress. Both iron (Fe) and oxygen are involved in the chemical reactions that lead to increased formation of reactive oxygen species.
M. Kentson, P. Leanderson, P. Jacobson, H. L. Persson   +3 more
doaj   +1 more source