Results 51 to 60 of about 1,044,480 (214)

Efficacy of intravenous iron treatment for chemotherapy-induced anemia: A prospective Phase II pilot clinical trial in South Korea.

PLoS Medicine, 2020
BackgroundAnemia is the most common and serious cancer-related complication. This study aimed to evaluate the efficacy of administration of ferric carboxymaltose without erythropoiesis-stimulating agents for treating anemia in cancer patients.
Jun Ho Jang, Youjin Kim, Silvia Park, Kihyun Kim, Seok Jin Kim, Won Seog Kim, Chul Won Jung, Jeeyun Lee, Se-Hoon Lee   +8 more
doaj   +1 more source

Comparative Analysis of Poly(Ethylene Glycol) (PEG) and Poly(2‐Ethyl‐2‐Oxazoline) (PEtOx) for Organic Solvent‐Free Lipid Nanoparticle Formulations

Angewandte Chemie International Edition, EarlyView.
Organic solvent‐free lipid nanoparticles featuring PEtOx‐based stealth lipids enable efficient mRNA and CRISPR‐Cas9 delivery while exhibiting markedly improved biocompatibility compared with PEG‐based analogues. Their successful ex vivo and in vivo performance, combined with data‐driven formulation optimization, establishes a versatile platform that ...
Michael Streiber, Caroline T. Holick, Lucas Gath, Ekaterina Tsarenko, Vivien Bachmann, Stavroula Litsiou, Lukas Harder, Laura J. Rosenberger, Aleksandar Rusevski, Julian Kimmig, Stephan Culemann, Christian Franke, Claudia Waskow, Stephanie Hoeppener, Stephanie Schubert, Matthias Bros, Oliver Werz, Ivo Nischang, Michael Bauer, Adrian T. Press, Ulrich S. Schubert, Anja Traeger   +21 more
wiley   +1 more source

Recent Advances in Virus–Host Interactions, Antiviral Bioactive Compounds, and Breeding for Disease Resistance of Porcine Epidemic Diarrhea Virus

Animal Research and One Health, EarlyView.
Basic research on the PEDV infection cycle and virus–host interactions advances the development of anti‐PEDV drugs and disease‐resistant breeding and helps strengthen disease prevention and control while reducing economic losses in the swine industry.
Heyong Wu, Aosi Qi, Shuyu Zhong, Haozhen Du, Shimeng Guo, Hongsheng Ouyang, Hongming Yuan, Daxin Pang, Zicong Xie   +8 more
wiley   +1 more source

IRON DEFICIENCY ANEMIA AND ANEMIA OF CHRONIC DISEASES: SOME ASPECTS OF THE PATHOGENESIS AND PROSPECTS OF DIFFERENTIAL DIAGNOSIS

Медицина в Кузбассе, 2019
Objective – to evaluate the information content of modern methods for studying iron metabolism in the algorithm for the differential diagnosis of hypochromic anemias. Materials and methods. A total of 296 women aged 16 to 60 years with an anemic syndrome
Сатеник Аршавиловна Клочкова-Абельянц, Галина Северьевна Суржикова   +1 more
doaj  

Iron Profile of Sickle Cell Disease Patients in Aminu Kano Teaching Hospital, Kano, Nigeria

Nigerian Journal of Medicine
Background: Sickle cell disease (SCD) is an inherited chronic haemolytic disorder that is characterised by chronic anaemia and recurrent body pains, with Nigeria accounting for the highest burden globally.
Awwal Musa Borodo, Usman Muhammad Ibrahim, Hauwa Ibrahim, Nabila Ado Yau, Aisha Kuliya-Gwarzo, Sagir Gumel Ahmed   +5 more
doaj   +1 more source

Physiologic cold shock of Moraxella catarrhalis affects the expression of genes involved in the iron acquisition, serum resistance and immune evasion

BMC Microbiology, 2011
Background Moraxella catarrhalis, a major nasopharyngeal pathogen of the human respiratory tract, is exposed to rapid downshifts of environmental temperature when humans breathe cold air.
Schaller André, Troller Rolf, Spaniol Violeta, Aebi Christoph   +3 more
doaj   +1 more source

Revisiting Inherited Metabolic Diseases (IMDs) Through the Lens of Selective Autophagy [PDF]

J Inherit Metab Dis
ABSTRACT Selective autophagy is increasingly recognized as a fundamental quality‐control mechanism that complements bulk autophagy by enabling the targeted degradation of specific intracellular cargos, including mitochondria, endoplasmic reticulum (ER), lipid droplets, glycogen, peroxisomes, ferritin, ribosomes, and protein aggregates.
Maddaluno M, Cinque L, Cetrangolo V, De Leonibus C.   +3 more
europepmc   +2 more sources

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

Iron status in children with acute COVID-19 and paediatric inflammatory multisystem syndrome during infection and after recovery

Egyptian Pediatric Association Gazette
Background COVID-19 has significant effects on organ function, particularly on lung function and iron metabolism. Studies have shown increased levels of ferritin, an iron storage protein, in COVID-19 patients, indicating potential changes in iron ...
Mai S. El-Meshad, Angi Adel Alwakeel, Reham M. El-Farahaty, Hyam Sameh Nada, Mayada S. Zeid   +4 more
doaj   +1 more source

Human amniotic fluid glycoproteins expressing sialyl Lewis carbohydrate antigens stimulate progesterone production in human trophoblasts in vitro [PDF]

, 2004
Background: Progesterone is thought to mediate immune modulator effects by regulating uterine responsiveness. The aim of the study was to clarify the effect of transferrin and glycodelin A (former name PP14) as sialyl Lewis X-expressing glycoproteins on ...
Streu, Annett, Richter, Dagmar-Ulrike, Volker Briese, Jeschke, Udo, Klaus Friese, Ioannis Mylonas, Annett Streu, Udo Jeschke, Briese, Volker, Mylonas, Ioannis, Müller, Heiner, Dagmar-Ulrike Richter, Friese, Klaus, Heiner Müller   +13 more
core   +1 more source