Results 21 to 30 of about 1,856,875 (191)

Soluble Urokinase Plasminogen Activator Receptor (SuPAR) Analysis for Diagnosis of Periprosthetic Joint Infection [PDF]

Antibiotics
Soluble urokinase plasminogen activator receptors (suPARs) are a biomarker for inflammatory diseases. This study aims to investigate its diagnostic properties regarding periprosthetic joint infections (PJI). This retrospective cohort study included adult
Sebastian M. Klim, Jürgen Prattes, Florian Amerstorfer, Tobias Niedrist, Christoph Zurl, Martin Stradner, Barbara Dreo, Gunther Glehr, Andreas Leithner, Mathias Glehr, Patrick Reinbacher, Patrick Sadoghi, Georg Hauer   +12 more
doaj   +2 more sources

Immune Activation Mediates the Association of Advanced Hepatic Fibrosis With Adverse Outcomes in Patients With Coronary Artery Disease

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Literature suggests a bidirectional association between advanced hepatic fibrosis (AHF) and coronary artery disease (CAD). We evaluated the association of AHF with immune activation, systemic inflammation, and adverse outcomes in patients with
Vardhmaan Jain, Anurag Mehta, Terence B. Lee, Chang Liu, Nicholas W. S. Chew, Yi‐An Ko, Matthew E. Gold, Daniel A. Gold, Nishant Vatsa, Shivang R. Desai, Jonathan H. Kim, Alireza Rahbar, Yazan Haroun, Kiran Ejaz, Salim S. Hayek, Mohammad S. Siddiqui, Fadi N. Salloum, Laurence S. Sperling, Arun J. Sanyal, Arshed A. Quyyumi   +19 more
doaj   +1 more source

Thrombo-inflammatory biomarkers to predict sepsis outcome

International Journal of Immunopathology and Pharmacology, 2021
Background: Sepsis has been redefined recently as life-threatening organ dysfunction caused by dysregulated host responses to infection and septic shock. Soluble urokinase plasminogen activator receptor (SuPAR) and plasminogen activator inhibitor-1(PAI-1)
Alaa Efat, Sabry Abdallah Shoeib, Ayman F Arafa, Ashraf Abdelraof Dawod, Mohamad A Abd ElHafez, Essam A Abd ElMohsen, Hany F Eladly, Reda A Ibrahim, Aly Elkholy   +8 more
doaj   +1 more source

Values of serum PCT, suPAR combined with severity scores for evaluating prognosis of septic shock patients

Romanian Journal of Laboratory Medicine, 2021
Background: To explore the values of serum procalcitonin (PCT), soluble urokinase-type plasminogen activator receptor (suPAR) combined with APACHE II and SOFA scores for evaluating the prognosis of septic shock patients.
Wang Wenxin, Jie Yingxin, Zhou Jia
doaj   +1 more source

Enhancement of the Enzymatic Activity of Single-chain Urokinase Plasminogen Activator by Soluble Urokinase Receptor [PDF]

Journal of Biological Chemistry, 1995
Single-chain urokinase (scuPA), the unique form of urokinase secreted by cells, is converted to an active two-chain molecule through the cleavage of a single peptide bond by plasmin and other specific proteinases. Although scuPA may express limited enzymatic activity, its contribution to plasminogen activation on cell surfaces remains uncertain ...
A, Higazi, R L, Cohen, J, Henkin, D, Kniss, B S, Schwartz, D B, Cines   +5 more
openaire   +2 more sources

Soluble urokinase plasminogen activator receptor level in individuals of advanced age [PDF]

Scientific Reports, 2020
AbstractSoluble urokinase plasminogen activator receptor (suPAR) is a biomarker whose clinical value has been tested in various groups of patients. The aim of the present study was to determine the suPAR level in a previously uninvestigated population of 182, generally healthy, community-dwelling seniors aged 74–89 years.
Wlazel, Rafal N., Szwabe, Katarzyna, Guligowska, Agnieszka, Kostka, Tomasz   +3 more
openaire   +2 more sources

Crystal structure and cellular functions of uPAR dimer

Nature Communications, 2022
The structural basis for urokinase-type plasminogen activator receptor (uPAR) dimerization is not understood. Here, the authors solve the crystal structure of soluble uPAR dimers, identifying substantial structural changes compared to the monomer.
Shujuan Yu, Yaqun Sui, Jiawei Wang, Yongdong Li, Hanlin Li, Yingping Cao, Liqing Chen, Longguang Jiang, Cai Yuan, Mingdong Huang   +9 more
doaj   +1 more source

suPAR, a Circulating Kidney Disease Factor

Frontiers in Medicine, 2021
Urokinase plasminogen activator receptor (uPAR) is a multifaceted, GPI-anchored three-domain protein. Release of the receptor results in variable levels of soluble uPAR (suPAR) in the blood circulation.
Changli Wei, Ryan Spear, Eunsil Hahm, Jochen Reiser   +3 more
doaj   +1 more source

Soluble Urokinase-Type Plasminogen Activator Receptor in FSGS [PDF]

Journal of the American Society of Nephrology, 2014
The soluble urokinase-type plasminogen activator receptor (suPAR) has been proposed as a candidate circulating factor causing FSGS.[1][1] In this issue of JASN , Cathelin et al. further examine the short-term effects of two different types of suPAR on the kidney filtration barrier.[2][2 ...
Jochen, Reiser, Harold, Chapman
openaire   +2 more sources

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source