Results 201 to 210 of about 5,197 (259)

Characterization of soman-binding antibodies raised against soman analogs

Molecular Immunology, 1992
The production of antibodies against the highly toxic organophosphorus compound soman (GD) has been undertaken. Monoclonal antibodies were raised against two structural analogs of soman which served as haptens for immunization. In these soman analogs the chemically active P-F bond of the soman molecule was substituted by a P-OH group (which is ionized ...
M, Glikson, R, Arad-Yellin, M, Ghozi, L, Raveh, B S, Green, Z, Eshhar   +5 more
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A method for generating toxic vapors of soman: Toxicity of soman by inhalation in rats

Toxicology and Applied Pharmacology, 1985
A method for administration of highly toxic chemicals by inhalation was developed. The model has three features of special interest: (1) a diffusion cell for producing a constant gas concentration, if necessary for several hours and days, (2) a small rapidly equilibrated inhalation chamber (1100 ml), and (3) complete isolation of the toxic chemicals ...
P, Aas, S H, Sterri, H P, Hjermstad, F, Fonnum   +3 more
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A pharmacodynamic model for soman in the rat

Toxicology Letters, 1988
A pharmacodynamic model for inhibition of acetylcholinesterase (AChE) by soman was developed to describe the intertissue differences in AChE inhibition, the dose response of AChE to inhibition by soman, and the effect of differences in xenobiotic metabolism on soman toxicity.
D M, Maxwell, C P, Vlahacos, D E, Lenz
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Pathophysiology of Soman intoxication in primates

Toxicology and Applied Pharmacology, 1986
Adult baboons were monitored during intravenous infusion of Soman (1,2,2-trimethylpropyl ester, phosphonofluoridate). Three groups of animals were studied. Two groups were anesthetized with sodium pentobarbital (initial dose, 20 mg/kg), instrumented for measurement of systemic blood pressure (BP), pulmonary artery pressure, cardiac output (CO), ECG ...
A, Anzueto, G G, Berdine, G T, Moore, C, Gleiser, D, Johnson, C D, White, W G, Johanson   +6 more
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Toxicokinetics of the four stereoisomers of the nerve agent soman in atropinized rats—Influence of a soman simulator

Toxicology and Applied Pharmacology, 1987
The toxicokinetics of the four stereoisomers of C(+/-)P(+/-)-soman were investigated in anesthetized, atropinized, and artificially ventilated rats at iv doses of 6 (495 micrograms/kg) and 3 LD50. By integration of a thermodesorption/cold trap injector into our GLC analysis, the soman stereoisomers could be followed in rat blood down to a minimum ...
Benschop, H.P., Bijleveld, E.C., Jong, L.P.A. de, Wiel, H.J. van der, Helden, H.P.M. van   +4 more
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Neurochemical Mechanisms in Soman-induced Seizures

Journal of Applied Toxicology, 1997
This study examined brain regional neurotransmitter level changes as a function of seizure duration following soman intoxication. Rats, implanted with cortical electrodes and pretreated with HI-6, received a convulsant dose of soman. At selected times after seizure onset the EEG recording electrodes were removed and the animal was killed.
T M, Shih, J H, McDonough
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Absolute configuration of somane

Russian Chemical Bulletin, 1993
PhCH2Ct K2C% Some parameters of the synthesized compounds are given below: b.p./~ (t7, Torr), n/) 20, m.p./~ (for hydrochloride): la, 53--54 (1), 1.4893, 177.5--178.5 (el ref. 1); lb, 85--86 (1), 1.5251, 165--166; 2a, 52--53 (1), 1.4854, 225--226; 2b, 98 (1.5), 1.5242, 162--162.5; 5, 62 (1), 1.4531, 225--226; 6, --, --, 132.5--143; 7, 120 (1), 1.5132,--
K. F. Koehler, H. Zaddach, A. D. Kuntsevich, I. I. Chervin, R. G. Kostyanovsky   +4 more
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Binding of soman antidotes to acetylcholine receptors

Biochemical Pharmacology, 1987
It has been reported that several bis-quaternary compounds not necessarily having an oxime function can be used to treat soman poisoning in mice. The mechanism for this protection is not clear, but it has been proposed that such compounds may act by blocking muscarinic or nicotinic acetylcholine receptors.
C, Broomfield, I J, Dembure, J, Cuculis
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Soman-induced convulsions: The neuropathology revisited

Toxicology, 2005
The organophosphorus compound soman, an irreversible inhibitor of cholinesterases, produces seizure activity and related brain damage. Studies using various biochemical markers of programmed cell death (PCD) suggested that soman-induced cell damage in the brain was apoptotic rather than necrotic.
Valérie, Baille, Peter G H, Clarke, Guy, Brochier, Frédéric, Dorandeu, Jean-Marc, Verna, Elise, Four, Guy, Lallement, Pierre, Carpentier   +7 more
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Naked DNA prevents soman intoxication

Biochemical and Biophysical Research Communications, 2005
Paraoxonase (Q isoenzyme, PON1) can effectively hydrolyze chlorpyrifos-oxon (CPO), soman, sarin, and other organophosphates. Previous studies had indicated that the levels of serum PON1 in gene therapy with adenoviral vector could decrease the toxicity of CPO.
Ai Ling, Fu, Yu Xia, Wang, Man Ji, Sun
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